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Arabidopsis CYP707As Encode (+)-Abscisic Acid 8′-Hydroxylase, a Key Enzyme in the Oxidative Catabolism of Abscisic Acid1
TLDR
It is established that the CYP707A family plays a key role in regulating the ABA level through the 8′-hydroxylation of (+)-ABA. Expand
Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the
TLDR
Zerumbone is a food phytochemical that has distinct potentials for use in anti-inflammation, chemoprevention, and chemotherapy strategies, and alpha-humulene, a structural analog lacking only the carbonyl group in ZER, was virtually inactive in all experiments conducted, indicating that the alpha,beta-unsaturated carbony l group may play some pivotal roles in interactions with unidentified target molecule(s). Expand
Ursolic acid: an anti- and pro-inflammatory triterpenoid.
TLDR
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli. Expand
Targeting NOX, INOS and COX‐2 in inflammatory cells: Chemoprevention using food phytochemicals
TLDR
The cancer preventive potentials of several food phytochemicals targeting the induction of NOX, iNOS and COX‐2 are described. Expand
Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression.
TLDR
Dietary rutin ameliorates DSS-induced colitis, presumably by suppressing the induction of pro-inflammatory cytokines, and may be useful for the prevention and treatment of IBD and colorectal carcinogenesis. Expand
Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates.
TLDR
The involvement of the redox regulation on the induction of GSTP1 by BITC is suggested, as well as the structure-activity relationship of the isothiocyanates, which indicated that the ROI-producing activities closely correlated with their GST-inducing potencies. Expand
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.
TLDR
Attenuated total reflection-Fourier transform infrared spectroscopy spectra suggested that beta-sheet content of the Abeta mutants correlates with their aggregation, however, beta-turn is also a critical secondary structure because residues at positions 22 and 23 that preferably form two-residue beta- turn significantly enhanced the aggregative ability. Expand
Use of Vernonia amygdalina by wild chimpanzee: Possible roles of its bitter and related constituents
TLDR
Antiparasitic activity tests of these constituents together with quantitative analyses of the major active constituents, vernodalin and vernonioside B1, supported the hypothesis that Mahale chimpanzees control parasite-related diseases by ingesting the pith of this plant found to contain several steroid-related constituents. Expand
Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'-acetoxychavicol acetate.
TLDR
The results suggested that ROS from leukocytes including O2- plays an important role for continuous and excessive production of chemotactic factors, leading to chronic inflammation and hyperplasia, which are inhibitable by ACA. Expand
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