Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.

@article{Johnson2007DifferentialMB,
  title={Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.},
  author={Joanne E. Johnson and Rebecca E. Goulding and Ziwei Ding and Amir Partovi and Kira Anthony and Nadine Beaulieu and Ghazaleh Tazmini and Rosemary B. Cornell and Robert J. Kay},
  journal={The Biochemical journal},
  year={2007},
  volume={406 2},
  pages={
          223-36
        }
}
RasGRPs (guanine-nucleotide-releasing proteins) are exchange factors for membrane-bound GTPases. All RasGRP family members contain C1 domains which, in other proteins, bind DAG (diacylglycerol) and thus mediate the proximal signal-transduction events induced by this lipid second messenger. The presence of C1 domains suggests that all RasGRPs could be regulated by membrane translocation driven by C1-DAG interactions. This has been demonstrated for RasGRP1 and RasGRP3, but has not been tested… CONTINUE READING

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