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Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
Many proteins associated with the plasma membrane are known to partition into submicroscopic sphingolipid- and cholesterol-rich domains called lipid rafts, but the determinants dictating thisExpand
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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Akt/protein kinase B critically regulates the balance between cell survival and apoptosis. Phosphorylation of Akt at two key sites, the activation loop and the hydrophobic motif, activates the kinaseExpand
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Protein Kinase C: Structure, Function, and Regulation (*)
  • A. Newton
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1 December 1995
The protein kinase C family of enzymes transduces the myriad of signals promoting lipid hydrolysis. The prevalence of this enzyme family in signaling is exemplified by the diverse transductionExpand
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Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm.
  • A. Newton
  • Chemistry, Medicine
  • The Biochemical journal
  • 1 March 2003
Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylationExpand
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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
Akt/protein kinase B controls cell growth, proliferation, and survival. We recently discovered a novel phosphatase PHLPP, for PH domain leucine-rich repeat protein phosphatase, which terminates AktExpand
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Protein kinase C: poised to signal.
  • A. Newton
  • Biology, Medicine
  • American journal of physiology. Endocrinology and…
  • 1 March 2010
Nestled at the tip of a branch of the kinome, protein kinase C (PKC) family members are poised to transduce signals emanating from the cell surface. Cell membranes provide the platform for PKCExpand
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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
The target of rapamycin (TOR), as part of the rapamycin‐sensitive TOR complex 1 (TORC1), regulates various aspects of protein synthesis. Whether TOR functions in this process as part of TORC2 remainsExpand
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Regulation of protein kinase C.
  • A. Newton
  • Biology, Medicine
  • Current opinion in cell biology
  • 1 April 1997
Protein kinase C has been in the spotlight since the discovery two decades ago that it is activated by the lipid second messenger diacylglycerol. Despite protein kinase C's enduring stage presence,Expand
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