• Publications
  • Influence
Pharmacological properties of the ubiquitous natural product betulin.
TLDR
A new mechanism of action has been confirmed for some of the most promising anti-HIV derivatives, which makes them potentially useful additives to the current anti- HIV therapy. Expand
Determination of neutral carbohydrates by CZE with direct UV detection
TLDR
The optimized method was applied for the determination of neutral monosaccharides in lemon, pineapple, and orange juices and a cognac sample and the methodology is fast since no other sample preparation except dilution is required. Expand
Antinociception by Spinal and Systemic Oxycodone: Why Does the Route Make a Difference?: In Vitro and In Vivo Studies in Rats
TLDR
The low intrathecal potency of oxycodone in rats seems be related to its low efficacy and potency to stimulate &mgr;-opioid receptor activation in the spinal cord. Expand
Bovine Serum Albumin Decreases Km Values of Human UDP-Glucuronosyltransferases 1A9 and 2B7 and Increases Vmax Values of UGT1A9
TLDR
The presence of bovine serum albumin during the glucuronidation reaction leads to a large increase in the Vmax value of UGT1A9, in addition to lowering its Km value, and the effects of these BSA effects on different UGTs and the inhibitors that it may remove are found to be similar. Expand
Albumin Stimulates the Activity of the Human UDP-Glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the Effects Are Enzyme and Substrate Dependent
TLDR
The magnitude of the BSA effects appears to be substrate dependent, especially with respect to V max increases, and may be UGT subfamily dependent since K m decreases were observed in members of subfamilies 1A, 2A and 2B, whereas large Vmax increases were only found in several UGT1A members. Expand
Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.
TLDR
The plant Melissa officinalis L. has been used traditionally in the treatment of cognitive dysfunction and it showed a wide range of antioxidant properties and another important bioactivity is acetylcholinesterase inhibition, which the extract was screened for in the current investigation. Expand
Morphine, Oxycodone, Methadone and Its Enantiomers in Different Models of Nociception in the Rat
TLDR
In nerve injury pain, l-methadone showed the greatest antiallodynic potency in both mechanical and cold allodynia compared with the other opioids, with morphine showing the weakest effect. Expand
Brain-Derived Neurotrophic Factor Controls Activity-Dependent Maturation of CA1 Synapses by Downregulating Tonic Activationof Presynaptic Kainate Receptors
TLDR
BDNF–TrkB-dependent maturation of glutamatergic synapses is tightly associated with a loss of endogenous KAR activity, which suggests a critical role for BDNF TrkB signaling in fast activity-dependent regulation of KARs. Expand
UDP-Glucuronosyltransferases (UGTs) 2B7 and UGT2B17 Display Converse Specificity in Testosterone and Epitestosterone Glucuronidation, whereas UGT2A1 Conjugates Both Androgens Similarly
TLDR
Analysis of athletes' urine samples found that the main reason for such false-positive results in doping tests was a low epitestosterone glucuronide concentration not a high level of testosterone glucuronides. Expand
Betulin-derived compounds as inhibitors of alphavirus replication.
TLDR
In contrast to previous work on other viruses, the antiviral activity of 13 was mapped to take place in virus replication phase and the efficacy was also shown to be independent of external guanosine supplementation. Expand
...
1
2
3
4
5
...