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Chimerin 1

Known as: Chimaerin, alpha-1, CHN1, alpha Chimaerin 
A GTPase activating protein that is specific for RAC GTP-BINDING PROTEINS. It is expressed primarily in the brain and may be involved in signal… 
National Institutes of Health

Related topics

Related topics

16 relations
CHN1 geneCytoplasmic matrixDAG/PE-Binding DomainIn Blood

Broader (1)

GTPase-Activating Proteins

Papers overview

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2004
2004
α‐Chimaerin exists in a functional complex with the Cdk5 kinase in brain
Highly Cited
2003
Highly Cited
2003
Antipsychotic drug treatment alters expression of mRNAs encoding lipid metabolism-related proteins
Using an automated PCR-based genomics approach, TOtal Gene expression Analysis (TOGA®), we have examined gene expression profiles… 
Highly Cited
2001
Highly Cited
2001
α2-Chimaerin, a Cdc42/Rac1 Regulator, Is Selectively Expressed in the Rat Embryonic Nervous System and Is Involved in Neuritogenesis in N1E-115 Neuroblastoma Cells
Neuronal differentiation involves Rac and Cdc42 GTPases. α-Chimaerin, a Rac/Cdc42 regulator, occurs as α1- and alternatively… 
Highly Cited
1996
Highly Cited
1996
The C-terminal part of diacylglycerol kinase alpha lacking zinc fingers serves as a catalytic domain.
All mammalian diacylglycerol kinase (DGK) isoenzymes so far cloned consist of four conserved regions, namely, C1, C2 (tandem EF… 
Highly Cited
1994
Highly Cited
1994
Breakpoint cluster region gene product-related domain of n-chimaerin. Discrimination between Rac-binding and GTPase-activating residues by mutational analysis.
The breakpoint cluster region gene product (Bcr) is a GTPase-activating protein (GAP) for members of the Rho family, Cdc42Hs, and… 
Highly Cited
1993
Highly Cited
1993
The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation.
Highly Cited
1993
Highly Cited
1993
The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins.
Highly Cited
1992
Highly Cited
1992
Association between GTPase activators for Rho and Ras families
THE ras-related low-molecular-mass GTPases participate in signal transduction involving a variety of cellular functions… 
Highly Cited
1990
Highly Cited
1990
Human brain n-chimaerin cDNA encodes a novel phorbol ester receptor.
A human brain-specific cDNA encoding n-chimaerin, a protein of predicted molecular mass 34 kDa, has sequence identity with two… 
Highly Cited
1990
Highly Cited
1990
Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene.
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