GTPase-Activating Proteins

Known as: GTPase activating protein, GTPase-Activating Proteins [Chemical/Ingredient], GTPase Activating Proteins 
An extensive family of proteins that stimulates the GTPase activity of both heterotrimeric G proteins and GTP-binding ras-superfamily proteins.
National Institutes of Health

Related topics

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Narrower (33)

ARAP1 protein, humanARHGAP20 protein, humanARHGAP24 protein, humanARHGAP26 protein, human
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ARHGAP35 protein, humanGAPVD1 geneGTPase activator activityIn Blood
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Broader (3)

GTP Phosphohydrolase ActivatorsProteinsRASA1 wt Allele

Papers overview

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Highly Cited
2009
Highly Cited
2009
Regulation of cytokinesis by Rho GTPase flux
In animal cells, cytokinesis is powered by a contractile ring of actin filaments (F-actin) and myosin-2. Formation of the… (More)
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Highly Cited
2007
Highly Cited
2007
Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells.
Rab GTPases control vesicle movement and tethering membrane events in membrane trafficking. We used the 38 human Rab GTPase… (More)
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Highly Cited
2005
Highly Cited
2005
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein.
Insulin controls glucose flux into muscle and fat by regulating the trafficking of GLUT4 between the interior and surface of… (More)
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Review
2005
Review
2005
GTPase activating proteins: structural and functional insights 18 years after discovery
The conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and inorganic phosphate (Pi) by guanine nucleotide… (More)
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Highly Cited
2003
Highly Cited
2003
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
BACKGROUND Tuberous Sclerosis Complex (TSC) is a genetic disorder that occurs through the loss of heterozygosity of either TSC1… (More)
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Highly Cited
2001
Highly Cited
2001
Signal Transduction in Neuronal Migration Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway
The Slit protein guides neuronal and leukocyte migration through the transmembrane receptor Roundabout (Robo). We report here… (More)
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Highly Cited
1999
Highly Cited
1999
Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion.
Rap1 GTPase is activated by a variety of stimulations in many types of cells, but its exact functions remain unknown. In this… (More)
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Highly Cited
1999
Highly Cited
1999
Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome.
The Rab6 GTPase regulates intracellular transport at the level of the Golgi apparatus, probably in a retrograde direction. Here… (More)
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Highly Cited
1997
Highly Cited
1997
The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.
The tuberous sclerosis complex 2 (TSC2) is a tumor suppressor gene that plays a causative role in the autosomal dominant syndrome… (More)
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Review
1992
Review
1992
GTPase activating proteins.
Since Ras proteins negotiate many signalling pathways leading to cell growth or differentiation, the regulation of Ras activity… (More)
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