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GTPase-Activating Proteins

Known as: GTPase activating protein, GTPase-Activating Proteins [Chemical/Ingredient], GTPase Activating Proteins 
An extensive family of proteins that stimulates the GTPase activity of both heterotrimeric G proteins and GTP-binding ras-superfamily proteins.
National Institutes of Health

Related topics

Related topics

50 relations

Narrower (34)

ARAP1 protein, humanARHGAP20 protein, humanARHGAP26 protein, humanARHGAP5 protein, human
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ARHGAP35 protein, humanGAPVD1 geneGTPase activator activityIn Blood
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Broader (2)

GTP Phosphohydrolase ActivatorsProteins

Papers overview

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Review
2018
Review
2018
Regulation of RhoA GTPase and various transcription factors in the RhoA pathway
RhoA GTPase plays a variety of functions in regulation of cytoskeletal proteins, cellular morphology, and migration along with… Expand
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Highly Cited
2009
Highly Cited
2009
Regulation of cytokinesis by Rho GTPase flux
In animal cells, cytokinesis is powered by a contractile ring of actin filaments (F-actin) and myosin-2. Formation of the… Expand
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Highly Cited
2007
Highly Cited
2007
Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells
Rab GTPases control vesicle movement and tethering membrane events in membrane trafficking. We used the 38 human Rab GTPase… Expand
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Highly Cited
2005
Highly Cited
2005
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein.
Insulin controls glucose flux into muscle and fat by regulating the trafficking of GLUT4 between the interior and surface of… Expand
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Review
2005
Review
2005
GTPase activating proteins: structural and functional insights 18 years after discovery
Abstract.The conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and inorganic phosphate (Pi) by guanine… Expand
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Highly Cited
2003
Highly Cited
2003
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
BACKGROUND Tuberous Sclerosis Complex (TSC) is a genetic disorder that occurs through the loss of heterozygosity of either TSC1… Expand
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Highly Cited
2001
Highly Cited
2001
Signal Transduction in Neuronal Migration Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway
The Slit protein guides neuronal and leukocyte migration through the transmembrane receptor Roundabout (Robo). We report here… Expand
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Review
1998
Review
1998
Structure and function in GroEL-mediated protein folding.
Recent structural and biochemical investigations have come together to allow a better understanding of the mechanism of… Expand
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Highly Cited
1997
Highly Cited
1997
The Tuberous Sclerosis 2 Gene Product, Tuberin, Functions as a Rab5 GTPase Activating Protein (GAP) in Modulating Endocytosis*
The tuberous sclerosis complex 2 (TSC2) is a tumor suppressor gene that plays a causative role in the autosomal dominant syndrome… Expand
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Highly Cited
1996
Highly Cited
1996
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells
Individuals with neurofibromatosis type 1 (NF1) are predisposed to certain cancers including juvenile chronic myelogenous… Expand
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