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The mechanisms regulating hematopoietic stem and progenitor cell (HSPC) fate choices remain ill-defined. Here, we show that a… Expand BackgroundThe acquisition of inappropriate migratory feature is crucial for tumor metastasis. Rho-family GTPases including RhoA… Expand The GTP hydrolysis activities of Rho GTPases are stimulated by GTPase-activating proteins (GAPs), which contain a RhoGAP domain… Expand IntroductionRho GTPases are overexpressed and hyperactivated in human breast cancers. Deficiency of p190B RhoGAP, a major… Expand Abstract 575 Hematopoietic stem cells (HSC) are undifferentiated cells that are capable of self-renewal and production of all… Expand OBJECTIVE:To detect the expression of p190-B RhoGAP in lung adenocarcinoma and inverstigate its clinical significance. METHODS… Expand P190-B RhoGAP (p190-B, also known as ARHGAP5) has been shown to play an essential role in invasion of the terminal end buds (TEBs… Expand ABSTRACT Myogenesis is an intricate process that coordinately engages multiple intracellular signaling cascades. The Rho family… Expand Rho GTPases regulate several aspects of tissue morphogenesis during animal development. We found that mice lacking the Rho… Expand