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- Front. Cell. Neurosci.
Neuroinflammatory response is primarily a protective mechanism in the brain. However, excessive and chronic inflammatory… (More)
- Neuroscience & Biobehavioral Reviews
Converging lines of evidence suggest that the pathophysiology of pain is mediated to a substantial degree via allostatic… (More)
- Archives of general psychiatry
Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and… (More)
Corticotropin-releasing hormone (Crh) is a critical coordinator of the hypothalamic-pituitary-adrenal (HPA) axis. In response to… (More)
Corticotropin-releasing hormone (Crh), a 41-residue polypeptide, activates two G-protein–coupled receptors, Crhr1 (refs 3–5) and… (More)
- The American journal of psychiatry
The authors sought to carefully test, by using a technique of continuous CSF sampling, the hypothesis that basal… (More)
Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress… (More)
CORTICOTROPIN-RELEASING factor (CRF), a peptide first isolated from mammalian brain1, is critical in the regulation of the… (More)
The hypothalamo-pituitary-adrenal (HPA) axis is known to be activated in depressed patients. Although direct evidence is lacking… (More)
There is now evidence that the immune system, during times of infectious challenge, can stimulate the secretion of… (More)