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Corticotropin-Releasing Hormone

Known as: Corticotropin Releasing Factor, ACTH-Releasing Factor, Corticotropin-Releasing Hormone-41 
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR… Expand
National Institutes of Health

Related topics

Related topics

33 relations
CRH geneCRH wt AlleleCorticotropinCorticotropin releasing hormone:MCnc:Pt:Ser/Plas:Qn
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Broader (4)

HormonesHypothalamic HormonesNeuropeptidesPeptides

Narrower (8)

UCN3 protein, humanastressinastressin Bcortagine
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.
CONTEXT Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and… Expand
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Highly Cited
2000
Highly Cited
2000
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
Corticotropin-releasing hormone (Crh) is a critical coordinator of the hypothalamic-pituitary-adrenal (HPA) axis. In response to… Expand
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Highly Cited
2000
Highly Cited
2000
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated.
Clinical and preclinical data suggest that unrestrained secretion of corticoctropin-releasing hormone (CRH) in the CNS produces… Expand
Highly Cited
1998
Highly Cited
1998
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress… Expand
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Highly Cited
1995
Highly Cited
1995
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
CORTICOTROPIN-RELEASING factor (CRF), a peptide first isolated from mammalian brain1, is critical in the regulation of the… Expand
Highly Cited
1991
Highly Cited
1991
Petrosal sinus sampling with and without corticotropin-releasing hormone for the differential diagnosis of Cushing's syndrome.
BACKGROUND Measurement of adrenocorticotropin levels in plasma from the inferior petrosal sinuses of patients with Cushing's… Expand
Highly Cited
1987
Highly Cited
1987
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor.
There is now evidence that the immune system, during times of infectious challenge, can stimulate the secretion of… Expand
Highly Cited
1987
Highly Cited
1987
Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1.
Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and… Expand
Highly Cited
1986
Highly Cited
1986
Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing's disease. Pathophysiologic and diagnostic implications.
Primary depression can be associated with substantial hypercortisolism, thus prompting some researchers to suggest that… Expand
Highly Cited
1982
Highly Cited
1982
Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin
Initially the hypothalamic factor responsible for the release of corticotropin (CRF), was thought to be a simple peptide1–6. More… Expand
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