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Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and… Expand Corticotropin-releasing hormone (Crh) is a critical coordinator of the hypothalamic-pituitary-adrenal (HPA) axis. In response to… Expand Clinical and preclinical data suggest that unrestrained secretion of corticoctropin-releasing hormone (CRH) in the CNS produces… Expand Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress… Expand CORTICOTROPIN-RELEASING factor (CRF), a peptide first isolated from mammalian brain1, is critical in the regulation of the… Expand BACKGROUND
Measurement of adrenocorticotropin levels in plasma from the inferior petrosal sinuses of patients with Cushing's… Expand There is now evidence that the immune system, during times of infectious challenge, can stimulate the secretion of… Expand Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and… Expand Primary depression can be associated with substantial hypercortisolism, thus prompting some researchers to suggest that… Expand Initially the hypothalamic factor responsible for the release of corticotropin (CRF), was thought to be a simple peptide1–6. More… Expand