Corticotropin-Releasing Hormone

Known as: Corticotropin Releasing Factor, ACTH-Releasing Factor, Corticotropin-Releasing Hormone-41 
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1951-2018
020040019512017

Related topics

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32 relations
CRH geneCRH wt AlleleCorticotropinCorticotropin releasing hormone:SCnc:Pt:Ser/Plas:Qn
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Broader (4)

HormonesHypothalamic HormonesNeuropeptidesPeptides

Narrower (8)

UCN3 protein, humanastressinastressin Bcortagine
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Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Corticotropin-Releasing Hormone
standards characteristics
physiological aspects
Hypothalamic structure
Corticotropin
Neuropeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration
Neuroinflammatory response is primarily a protective mechanism in the brain. However, excessive and chronic inflammatory… (More)
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Review
2016
Review
2016
Reward deficiency and anti-reward in pain chronification
Converging lines of evidence suggest that the pathophysiology of pain is mediated to a substantial degree via allostatic… (More)
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Highly Cited
2008
Highly Cited
2008
Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.
CONTEXT Genetic inheritance and developmental life stress both contribute to major depressive disorder in adults. Child abuse and… (More)
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Highly Cited
2000
Highly Cited
2000
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress
Corticotropin-releasing hormone (Crh) is a critical coordinator of the hypothalamic-pituitary-adrenal (HPA) axis. In response to… (More)
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Highly Cited
2000
Highly Cited
2000
Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
Corticotropin-releasing hormone (Crh), a 41-residue polypeptide, activates two G-protein–coupled receptors, Crhr1 (refs 3–5) and… (More)
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Highly Cited
1999
Highly Cited
1999
Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder.
OBJECTIVE The authors sought to carefully test, by using a technique of continuous CSF sampling, the hypothesis that basal… (More)
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Highly Cited
1998
Highly Cited
1998
Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1
Corticotropin-releasing hormone (CRH) is a potent mediator of endocrine, autonomic, behavioural and immune responses to stress… (More)
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Highly Cited
1995
Highly Cited
1995
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
CORTICOTROPIN-RELEASING factor (CRF), a peptide first isolated from mammalian brain1, is critical in the regulation of the… (More)
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Highly Cited
1994
Highly Cited
1994
Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients.
The hypothalamo-pituitary-adrenal (HPA) axis is known to be activated in depressed patients. Although direct evidence is lacking… (More)
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Highly Cited
1987
Highly Cited
1987
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor.
There is now evidence that the immune system, during times of infectious challenge, can stimulate the secretion of… (More)
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