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Stress and the brain: from adaptation to disease
New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified in genetically predisposed individuals. Expand
The Corticosteroid Receptor Hypothesis of Depression
  • F. Holsboer
  • Biology, Medicine
  • Neuropsychopharmacology
  • 1 November 2000
Mouse genetics, allowing for selective inactivation of genes relevant for HPA regulation and molecular pharmacology, dissecting the intracellular cascade of CR signaling, are the most promising future research fields, suited for identifying genes predisposing to depression. Expand
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
It is found that a functional polymorphism altering chromatin interaction between the transcription start site and long-range enhancers in the FK506 binding protein 5 gene increased the risk of developing stress-related psychiatric disorders in adulthood by allele-specific, childhood trauma–dependent DNA demethylation in functional glucocorticoid response elements of FKBP5. Expand
Differential signal transduction by five splice variants of the PACAP receptor
A new expression cloning strategy, based on the induction of a reporter gene by cyclic AMP, is used to isolate a complementary DNA encoding the type-I PACAP receptor, suggesting a novel mechanism for fine tuning of signal transduction. Expand
Dynamic DNA methylation programs persistent adverse effects of early-life stress
It is found that neuronal activity controlled the ability of MeCP2 to regulate activity-dependent transcription of the Avp gene and induced epigenetic marking, which can dynamically control DNA methylation in postmitotic neurons to generate stable changes in Avp expression that trigger neuroendocrine and behavioral alterations that are frequent features in depression. Expand
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
It is proposed that the FKBP5 variant–dependent alterations in HPA-axis regulation could be related to the faster response to antidepressant drug treatment and the increased recurrence of depressive episodes observed in this subgroup of depressed individuals. Expand
The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders.
This report summarizes our extensive experience with the application of the DEX/CRH test to assess hypothalamic-pituitary-adrenal-system (HPA) alteration in patients with psychiatric disorders. TheExpand
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
Antidepressants and hypothalamic-pituitary-adrenocortical regulation.
It is shown that antidepressants interfere not only with the production and release of catecholamines and indolamines but also with the signal transduction of those neurotransmitters that have long been implicated in the pathogenesis and treatment of depression. Expand
Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy.
  • F. Holsboer
  • Psychology, Medicine
  • Journal of affective disorders
  • 2001
A summary of studies sustaining that view is given and data are presented which demonstrate that depression is associated with an impairment of corticosteroid receptor function that gives rise to an excessive release of neurohormones to which a number of signs and symptoms characteristic of depression can be attributed. Expand