Stress and the brain: from adaptation to disease
- E. R. Kloet, M. Joëls, F. Holsboer
- BiologyNature Reviews Neuroscience
- 1 June 2005
New candidate susceptibility genes that serve as markers for the prediction of vulnerable phenotypes are now being identified in genetically predisposed individuals.
The Corticosteroid Receptor Hypothesis of Depression
- F. Holsboer
- BiologyNeuropsychopharmacology
- 1 November 2000
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
- T. Klengel, D. Mehta, E. Binder
- Biology, PsychologyNature Neuroscience
- 2013
It is found that a functional polymorphism altering chromatin interaction between the transcription start site and long-range enhancers in the FK506 binding protein 5 gene increased the risk of developing stress-related psychiatric disorders in adulthood by allele-specific, childhood trauma–dependent DNA demethylation in functional glucocorticoid response elements of FKBP5.
Differential signal transduction by five splice variants of the PACAP receptor
- Dietmar Spongier, C. Waeber, L. Journot
- BiologyNature
- 9 September 1993
A new expression cloning strategy, based on the induction of a reporter gene by cyclic AMP, is used to isolate a complementary DNA encoding the type-I PACAP receptor, suggesting a novel mechanism for fine tuning of signal transduction.
Dynamic DNA methylation programs persistent adverse effects of early-life stress
- C. Murgatroyd, A. Patchev, D. Spengler
- BiologyNature Neuroscience
- 1 December 2009
It is found that neuronal activity controlled the ability of MeCP2 to regulate activity-dependent transcription of the Avp gene and induced epigenetic marking, which can dynamically control DNA methylation in postmitotic neurons to generate stable changes in Avp expression that trigger neuroendocrine and behavioral alterations that are frequent features in depression.
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
- E. Binder, D. Salyakina, Bertram Muller-Myhsok
- Biology, PsychologyNature Genetics
- 1 December 2004
It is proposed that the FKBP5 variant–dependent alterations in HPA-axis regulation could be related to the faster response to antidepressant drug treatment and the increased recurrence of depressive episodes observed in this subgroup of depressed individuals.
The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders.
- I. Heuser, A. Yassouridis, F. Holsboer
- Medicine, PsychologyJournal of Psychiatric Research
- 1 July 1994
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Antidepressants and hypothalamic-pituitary-adrenocortical regulation.
- F. Holsboer, N. Barden
- Biology, PsychologyEndocrine reviews
- 1 April 1996
It is shown that antidepressants interfere not only with the production and release of catecholamines and indolamines but also with the signal transduction of those neurotransmitters that have long been implicated in the pathogenesis and treatment of depression.
Development of the brain's default mode network from wakefulness to slow wave sleep.
Functional connectivity analysis of rs-fMRI series obtained from 25 healthy participants found significant changes in DMN/ACN integrity throughout the NREM sleep, and it is submitted that preserved corticocortical synchronization could represent a prerequisite for maintaining internal and external awareness.
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