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Identification of late-onset hypogonadism in middle-aged and elderly men.
TLDR
Symptoms of poor morning erection, low sexual desire, erectile dysfunction, inability to perform vigorous activity, depression, and fatigue were significantly related to the testosterone level, and an inverse relationship between an increasing number of sexual symptoms and a decreasing testosterone level was observed. Expand
Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging.
TLDR
A marked decline in circulating adrenal C19 steroids and their resulting androgen metabolites takes place between the age groups of 20- to 30-yr olds and 50- to 60-yr-olds, with smaller changes observed after the age of 60 yr, suggesting a parallel decrease in the total androgen pool with age. Expand
Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta.
TLDR
The results demonstrate that while ER beta shares many of the functional characteristics of ER alpha, the molecular mechanisms regulating the transcriptional activity of mER beta may be distinct from those of ERalpha. Expand
Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone.
TLDR
DHEA has been found to increase bone mineral density and to stimulate vaginal maturation without affecting the endometrium, while improving well-being and libido with no significant side effects and thus minimizing the potential side effects observed with androgens or estrogens administered systemically. Expand
Is dehydroepiandrosterone a hormone?
TLDR
The new field of intracrinology or local formation of sex steroids from DHEA in target tissues has permitted major advances in the treatment of the two most frequent cancers, namely breast and prostate cancer, while its potential use as a physiological HRT could well provide a physiological balance of androgens and estrogens, thus offering exciting possibilities for women's health at menopause. Expand
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds
TLDR
The complete coding sequence and exonic structure of BRCA2 is determined, and its pattern of expression is examined, and a mutational analysis of B RCA2 in families selected on the basis of linkage analysis and/or the presence of one or more cases of male breast cancer is reported. Expand
Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1.
TLDR
It is demonstrated here that phosphorylation of AF-1 by MAP kinase (MAPK) leads to the recruitment of steroid receptor coactivator-1 (SRC-1) by ER beta in vitro and provides a molecular basis for ligand-independent activation by ERbeta via the MAPK pathway. Expand
Androgen biosynthetic pathways in the human prostate.
TLDR
The present chapter reviews the literature obtained from various human, dog, rat and mouse prostate tissues, as well as primary cells and prostatic cancer cell lines, to provide a clearer picture of the pathways involved in DHT biosynthesis and metabolism in the human prostate. Expand
A candidate prostate cancer susceptibility gene at chromosome 17p
TLDR
A genome-wide scan of large, high-risk pedigrees from Utah has provided evidence for linkage to a locus on chromosome 17p, identifying a gene, ELAC2, harboring mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two pedigree. Expand
Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs.
TLDR
The present findings indicate a cell-specific localization of ERalpha, ERbeta and AR in reproductive tissues in rats of both sexes, which contribute to a better understanding of the respective role of these steroids in reproduction function. Expand
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