Coformycin

Known as: Coformycin [Chemical/Ingredient], Imidazo(4,5-d)(1,3)diazepin-8-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl-, (R)- 
A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2011
012319752011

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2007
2007
Transition state theory suggests that enzymatic rate acceleration (kcat/knon) is related to the stabilization of the transition… (More)
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1995
1995
2',3'-dideoxyadenosine (ddAdo) and 2',3'-dideoxyinosine (ddIno) are potent and selective inhibitors of the replication of the… (More)
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1993
1993
Human fibroblast lysosomes, purified on Percoll density gradients, contain an adenosine deaminase (ADA) activity that accounts… (More)
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1988
1988
Coformycin resistance in Chinese hamster fibroblasts is associated with co-amplification of four unknown genes (i.e. W, X, Y1, Y2… (More)
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1985
1985
Coformycin, which is an inhibitor of adenosine deaminase, significantly inhibited in vitro blastogenic responses of human… (More)
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1983
1983
Kinetic studies with platelet AMP deaminase, at pH 7.0 and 100 mM NaC1, gave cooperative initial velocity curves with AMP as… (More)
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1983
1983
The inhibition of S-adenosylhomocysteine hydrolase and accumulation of dATP in thymus, spleen and other tissues of mice treated… (More)
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1982
1982
The effects of coformycin, a highly potent and specific inhibitor of the intracellular enzyme adenosine deaminase and the… (More)
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1981
1981
The intracellular adenosine deaminase activity of induced macrophages was twice that of resident cells. Coformycin, a specific… (More)
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1976
1976
Deficiency of erythrocytic and lymphocytic adenosine deaminase (ADA) occurs in some patients with severe combined… (More)
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