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Coformycin

Known as: Coformycin [Chemical/Ingredient], Imidazo(4,5-d)(1,3)diazepin-8-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl-, (R)- 
A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is… Expand
National Institutes of Health

Papers overview

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Highly Cited
1997
Highly Cited
1997
The purine nucleoside adenosine (9-beta-D-ribofuranosyladenine) inhibits a number of lymphocyte functions in vitro, including the… Expand
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Highly Cited
1980
Highly Cited
1980
1. The catabolism of purine nucleotides was investigated by both chemical and radiochemical methods in isolated rat hepatocytes… Expand
Highly Cited
1977
Highly Cited
1977
Abstract The specificity of the potent adenosine deaminase inhibitors deoxycoformycin (covidarabine), coformycin and erythro -9… Expand
Highly Cited
1976
Highly Cited
1976
High concentrations of adenosine are known to be toxic to fibroblasts and lymphocytes under conditions of in vitro culture (1,2… Expand
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Highly Cited
1976
Highly Cited
1976
  • S. Cha
  • Biochemical pharmacology
  • 1976
  • Corpus ID: 44252071
Abstract Equations have been developed which provide the basis for the elucidation of the inhibition mechanism of a tight-binding… Expand
Highly Cited
1976
Highly Cited
1976
The association of a human genetic deficiency of adenosine deaminase activity with combined immunodeficiency prompted a study of… Expand
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Highly Cited
1975
Highly Cited
1975
Abstract The non-steady state nature of the inhibition of milk xanthine oxidase by allopurinol and alloxanthine was demonstrated… Expand
Highly Cited
1975
Highly Cited
1975
Abstract Adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) has been purified about 3000-fold from human erythrocytes… Expand
Highly Cited
1975
Highly Cited
1975
In fat cells isolated from the parametrial adipose tissue of rats, the addition of purified adenosine deaminase increased… Expand
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Highly Cited
1974
Highly Cited
1974