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Site-selective cyclic AMP analogs as new biological tools in growth control, differentiation, and proto-oncogene regulation.
The physiologic role of cyclic adenosine monophosphate (cAMP) in the growth control of a spectrum of human cancer lines, including leukemic lines, and v-rasH oncogene-transformed NIH/3T3 cells isExpand
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Purine metabolism in the schistosomes: potential targets for chemotherapy.
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Pathways of nucleotide metabolism in Schistosoma mansoni. 3. Identification of enzymes in cell-free extracts.
Abstract A survey of purine anabolic and catabolic enzymes has resulted in identification of major pathways in schistosome nucleotide biosynthesis. It is shown that multiple pathways for theExpand
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Mechanism of activation of triciribine phosphate (TCN-P) as a prodrug form of TCN.
The tricyclic nucleotide triciribine phosphate (TCN-P) was synthesized as a water-soluble derivative of the tricyclic nucleoside TCN (L. B. Townsend et al, INSERM 81:37, 1978). Growth of L1210 cellsExpand
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Purine nucleoside metabolism in the erythrocytes of patients with adenosine deaminase deficiency and severe combined immunodeficiency.
Deficiency of erythrocytic and lymphocytic adenosine deaminase (ADA) occurs in some patients with severe combined immunodeficiency disease (SCID). SCID with ADA deficiency is inherited as anExpand
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5'-Methylthioadenosine phosphorylase-L. Substrate activity of 5'-deoxyadenosine with the enzyme from Sarcoma 180 cells.
Abstract 5′-Deoxy-5′-methylthioadenosine phosphorylase (MTA phosphorylase), an enzyme involved in the salvage of adenine moieties from 5′-deoxy-5′-methylthioadenosine (MTA) produced primarily duringExpand
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Activities of purine-metabolizing enzymes in human colon carcinoma cell lines and xenograft tumors.
Abstract The activities of eleven enzymes of purine metabolism have been determined in extracts of four human colon carcinoma cell lines (clones A and D of the heterogeneous DLD-1 line, HCT-15 andExpand
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Pathways of nucleotide metabolism in Schistosoma mansoni--VII. Inhibition of adenine and guanine nucleotide synthesis by purine analogs in intact worms.
Abstract Twelve analogs of adenosine or its related purines have been tested as single agents or in combinations as possible antischistosomal compounds. Measurements were made of the effect of theseExpand
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Analogs of purine and pyrimidine nucleosides have received considerable attention in many laboratories concerned with the development of chemotherapeutic agents for malignancies, viruses, andExpand
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