Biosynthesis, degradation and pharmacological importance of the fatty acid amides.
- Emma K. Farrell, D. Merkler
- Biology, ChemistryDrug Discovery Today
- 1 July 2008
Catalytic mechanism of yeast adenosine 5'-monophosphate deaminase. Zinc content, substrate specificity, pH studies, and solvent isotope effects.
- D. Merkler, V. Schramm
- Biology, ChemistryBiochemistry
- 8 June 1993
Alignment of the amino acid sequence for yeast AMP deaminase with that for mouse adenosine deaminationase demonstrates conservation of the Amino acids known from the X-ray crystal structure to bind to the zinc and to a transition-state analogue.
C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity.
- D. Merkler
- Biology, ChemistryEnzyme and Microbial Technology
- 1 June 1994
Kinetic mechanism and intrinsic isotope effects for the peptidylglycine alpha-amidating enzyme reaction.
- W. A. Francisco, D. Merkler, N. Blackburn, J. Klinman
- Biology, ChemistryBiochemistry
- 2 June 1998
The identity of intrinsic isotope effects for peptidylglycine alpha-hydroxylating monooxygenase and dopamine beta-mono oxygengenase with substrates of comparable reactivity extends similarities between the two enzymes significantly beyond sequence homology and cofactor requirements.
Enzymatic formation of C-terminal amides.
- R. Kulathila, K. Merkler, D. Merkler
- BiologyNatural product reports (Print)
- 1999
Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase.
- D. Merkler, K. Merkler, W. Stern, F. Fleming
- Biology, ChemistryArchives of Biochemistry and Biophysics
- 15 June 1996
It is shown that N-myristoylglycine is a substrate for peptidyl glycine alpha-amidating enzyme with a (V/K)app that is 55 +/- 4% of the value measured for D-Tyr-Val-Gly.
Identification of an arylalkylamine N‐acyltransferase from Drosophila melanogaster that catalyzes the formation of long‐chain N‐acylserotonins
- Daniel R. Dempsey, K. Jeffries, Ryan L. Anderson, Anne-Marie Carpenter, Santiago Rodriquez Opsina, D. Merkler
- Biology, ChemistryFEBS Letters
- 14 February 2014
Oleic acid derived metabolites in mouse neuroblastoma N18TG2 cells.
- D. Merkler, G. Chew, A. J. Gee, K. Merkler, Jean-Paul O Sorondo, Mitchell E. Johnson
- BiologyBiochemistry
- 11 September 2004
Results strongly indicate that N-oleoylglycine is an intermediate in oleamide biosynthesis and provide further evidence that PAM does have a role in primary fatty acid amide production in vivo.
Drosophila melanogaster as a model system to study long‐chain fatty acid amide metabolism
- K. Jeffries, Daniel R. Dempsey, A. Behari, Ryan L. Anderson, D. Merkler
- BiologyFEBS Letters
- 2 May 2014
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