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- Publications
- Influence
A drug burden index to define the functional burden of medications in older people.
- S. Hilmer, D. Mager, +9 authors D. Abernethy
- Medicine
- Archives of internal medicine
- 23 April 2007
BACKGROUND
Older people carry a high burden of illness for which medications are indicated, along with increased risk of adverse drug reactions. We developed an index to determine drug burden based… Expand
Effect of Obesity on the Pharmacokinetics of Drugs in Humans
- M. Hanley, D. Abernethy, D. Greenblatt
- Medicine
- Clinical pharmacokinetics
- 2010
The prevalence of obesity has dramatically increased in recent years and now includes a significant proportion of the world’s children, adolescents and adults. Obesity is linked to a number of… Expand
Pharmacokinetics and Clinical Effectiveness of Methylphenidate
- H. Kimko, J. T. Cross, D. Abernethy
- Medicine
- Clinical pharmacokinetics
- 1999
Methylphenidate is prescribed for over 90% of children in the US diagnosed as having attention-deficit hyperactivity disorder (ADHD). Although ADHD has been widely studied, the use of methylphenidate… Expand
Effect of Age, Gender, and Obesity on Midazolam Kinetics
- D. Greenblatt, D. Abernethy, A. Locniskar, J. Harmatz, R. Limjuco, R. Shader
- Medicine
- Anesthesiology
- 1 July 1984
&NA; The effects of age, sex, and obesity on the kinetics of single intravenous (iv) and oral doses of midazolam were evaluated in healthy volunteers who received 2.5‐5 mg of iv midazolam on one… Expand
Active Nitric Oxide Produced in the Red Cell under Hypoxic Conditions by Deoxyhemoglobin-mediated Nitrite Reduction*
- E. Nagababu, S. Ramasamy, D. Abernethy, J. Rifkind
- Medicine, Chemistry
- Journal of Biological Chemistry
- 21 November 2003
Recent studies have generated a great deal of interest in a possible role for red blood cells in the transport of nitric oxide (NO) to the microcirculation and the vascular effect of this nitric… Expand
Total Protein Methods and Their Potential Utility to Reduce the Risk of Food Protein Adulteration
- J. Moore, J. Devries, M. Lipp, J. Griffiths, D. Abernethy
- Chemistry
- 1 July 2010
Abstract: Kjeldahl and combustion (Dumas) methods are widely accepted for total protein determination but lack analytical selectivity for protein because they measure protein on the basis of sample… Expand
High‐Risk Prescribing and Incidence of Frailty Among Older Community‐Dwelling Men
- D. Gnjidic, S. Hilmer, +7 authors D. L. Le Couteur
- Medicine
- Clinical pharmacology and therapeutics
- 1 March 2012
Evidence about the association between treatment with high–risk medicines and frailty in older individuals is limited. We investigated the relationship between high–risk prescribing and frailty at… Expand
Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats
- D. Mager, Ruiqian Wan, +4 authors M. Mattson
- Biology, Medicine
- FASEB journal : official publication of the…
- 1 April 2006
Dietary restriction (DR) has been shown to increase life span, delay or prevent age‐associated diseases, and improve functional and metabolic cardiovascular risk factors in rodents and other species.… Expand
Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19
- S. Donahue, D. Flockhart, D. Abernethy, J. W. Ko
- Medicine
- Clinical pharmacology and therapeutics
- 1 November 1997
A patient who had taken a stable dose of phenytoin for 2 years had a coronary stent placed for unstable angina and ticlopidine was added to his therapeutic regimen. Twenty‐five days later, he was… Expand
Ca2+ sensors of L‐type Ca2+ channel
- C. Romanin, R. Gamsjaeger, +4 authors N. Soldatov
- Chemistry, Biology
- FEBS letters
- 29 December 2000
Ca2+‐induced inactivation of L‐type Ca2+ is differentially mediated by two C‐terminal motifs of the α1C subunit, L (1572–1587) and K (1599–1651) implicated for calmodulin binding. We found that motif… Expand