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A drug burden index to define the functional burden of medications in older people.
TLDR
The drug burden index demonstrates that anticholinergic and sedative drug exposure is associated with poorer function in community-dwelling older people and provides a useful evidence-based tool for assessing the functional effect of exposure to medications in this population.
Effect of Obesity on the Pharmacokinetics of Drugs in Humans
TLDR
Clinicians should design treatment regimens that account for any significant differences in the CL and Vd in the obese, using a size descriptor that corrects for differences in absolute CL between obese and non-obese individuals.
Pharmacokinetics and Clinical Effectiveness of Methylphenidate
TLDR
It is difficult to predict which children will have a favourable response to methylphenidate, and therefore dosage must be titrated for optimal effect and avoidance of toxicity in each child, and further studies of the relationship between the pharmacokinetic and pharmacodynamic properties are required to allow the development of optimal dosage regimens.
Effect of Age, Gender, and Obesity on Midazolam Kinetics
TLDR
Midazolam elimination half‐life (t1/2) after iv dosage was significantly prolonged in elderly (aged 60‐74 yr) versus young (24‐33 yr) males and in obese subjects (8.4 vs. 2.7, P < 0.001) and Vd was greater in the obese subjects even after correction for total weight, indicating disproportionate distribution of midAZolam into adipose weight.
Active Nitric Oxide Produced in the Red Cell under Hypoxic Conditions by Deoxyhemoglobin-mediated Nitrite Reduction*
TLDR
It is confirmed that nitrite reduction at reduced oxygen pressures is a major source for red cell NO and the formation and potential release from the red cell of this NO could have a major impact in regulating the flow of blood through the microcirculation.
Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats
TLDR
The results suggest an additional cardiovascular benefit of DR that merits further studies of this potential effect in humans, and alter spectral measures of heart rate and blood pressure variability in rats.
Total Protein Methods and Their Potential Utility to Reduce the Risk of Food Protein Adulteration.
TLDR
It is concluded that some existing highly selective methods for food protein measurement have potential for routine quality control, but their successful implementation will require matrix-specific validation and the use of supporting reference materials.
Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19
TLDR
Using human liver microsomes, it is shown that ticlopidine is a potent inhibitor of cytochrome P450 2C19, and the data emphasize the importance of CYP2C19 in the metabolism of phenytoin.
High‐Risk Prescribing and Incidence of Frailty Among Older Community‐Dwelling Men
TLDR
High–risk prescribing may contribute to frailty in community–dwelling older men and the Drug Burden Index, a dose–normalized measure of anticholinergic and sedative medicines, in 1,662 men ≥70 years of age.
Stereochemistry of an Agonist Determines Coupling Preference of β2-Adrenoceptor to Different G Proteins in Cardiomyocytes
TLDR
The hypothesis that the stereochemistry of an agonist determines selectivity of receptor coupling to different G protein(s) is tested and it is found that the R,R isomers of fenoterol and methoxyfenoterol exhibited more potent effects to increase cardiomyocyte contraction than their S, R isomers.
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