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A drug burden index to define the functional burden of medications in older people.
BACKGROUND Older people carry a high burden of illness for which medications are indicated, along with increased risk of adverse drug reactions. We developed an index to determine drug burden basedExpand
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Effect of Obesity on the Pharmacokinetics of Drugs in Humans
The prevalence of obesity has dramatically increased in recent years and now includes a significant proportion of the world’s children, adolescents and adults. Obesity is linked to a number ofExpand
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Pharmacokinetics and Clinical Effectiveness of Methylphenidate
Methylphenidate is prescribed for over 90% of children in the US diagnosed as having attention-deficit hyperactivity disorder (ADHD). Although ADHD has been widely studied, the use of methylphenidateExpand
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Effect of Age, Gender, and Obesity on Midazolam Kinetics
&NA; The effects of age, sex, and obesity on the kinetics of single intravenous (iv) and oral doses of midazolam were evaluated in healthy volunteers who received 2.5‐5 mg of iv midazolam on oneExpand
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Active Nitric Oxide Produced in the Red Cell under Hypoxic Conditions by Deoxyhemoglobin-mediated Nitrite Reduction*
Recent studies have generated a great deal of interest in a possible role for red blood cells in the transport of nitric oxide (NO) to the microcirculation and the vascular effect of this nitricExpand
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Total Protein Methods and Their Potential Utility to Reduce the Risk of Food Protein Adulteration.
  Kjeldahl and combustion (Dumas) methods are widely accepted for total protein determination but lack analytical selectivity for protein because they measure protein on the basis of sample nitrogenExpand
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High‐Risk Prescribing and Incidence of Frailty Among Older Community‐Dwelling Men
Evidence about the association between treatment with high–risk medicines and frailty in older individuals is limited. We investigated the relationship between high–risk prescribing and frailty atExpand
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Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19
A patient who had taken a stable dose of phenytoin for 2 years had a coronary stent placed for unstable angina and ticlopidine was added to his therapeutic regimen. Twenty‐five days later, he wasExpand
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Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats
Dietary restriction (DR) has been shown to increase life span, delay or prevent age‐associated diseases, and improve functional and metabolic cardiovascular risk factors in rodents and other species.Expand
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Ca2+ sensors of L‐type Ca2+ channel
Ca2+‐induced inactivation of L‐type Ca2+ is differentially mediated by two C‐terminal motifs of the α1C subunit, L (1572–1587) and K (1599–1651) implicated for calmodulin binding. We found that motifExpand
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