Adenosine and brain function.
Neuroprotection by adenosine in the brain: From A1 receptor activation to A2A receptor blockade
- R. Cunha
- Biology, PsychologyPurinergic Signalling Purinergic Signalling
- 17 March 2005
The brain neuroprotective effect of A2AR antagonists is maintained in chronic noxious brain conditions without observable peripheral effects, thus justifying the interest of A 2AR antagonists as novel protective agents in neurodegenerative diseases such as Parkinson's and Alzheimer’s disease, ischemic brain damage and epilepsy.
Adenosine as a neuromodulator and as a homeostatic regulator in the nervous system: different roles, different sources and different receptors
- R. Cunha
- BiologyNeurochemistry International
- 1 February 2001
Adenosine A2A Receptors Are Essential for Long-Term Potentiation of NMDA-EPSCs at Hippocampal Mossy Fiber Synapses
Adenosine receptors and brain diseases: neuroprotection and neurodegeneration.
Dual Presynaptic Control by ATP of Glutamate Release via Facilitatory P2X1, P2X2/3, and P2X3 and Inhibitory P2Y1, P2Y2, and/or P2Y4 Receptors in the Rat Hippocampus
- R. Rodrigues, T. Almeida, P. Richardson, C. Oliveira, R. Cunha
- BiologyJournal of Neuroscience
- 6 July 2005
It is reported that ATP analogs biphasically modulate the evoked release of glutamate from purified nerve terminals of the rat hippocampus and coincident functional and molecular evidence that P2 receptors are present and act presynaptically as a modulatory system controlling hippocampal glutamate release is provided.
Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers
It is demonstrated that heteromerization of adenosine A1 receptors and A2A receptors allowsAdenosine to exert a fine-tuning modulation of glutamatergic neurotransmission and that chronic caffeine treatment leads to modifications in the function of the A1R–A2AR heteromer that could underlie the strong tolerance to the psychomotor effects of caffeine.
Involvement of Cannabinoid Receptors in the Regulation of Neurotransmitter Release in the Rodent Striatum: A Combined Immunochemical and Pharmacological Analysis
The results indicate distinct modulation of striatal GABAergic and glutamatergic transmission by cannabinoids and will facilitate the understanding of the role and importance of the cannabinoid system in normal and pathological motor function.
Inhibition by ATP of Hippocampal Synaptic Transmission Requires Localized Extracellular Catabolism by Ecto-Nucleotidases into Adenosine and Channeling to Adenosine A1 Receptors
The present results indicate that inhibition byextracellular ATP of hippocampal synaptic transmission requires localized extracellular catabolism by ecto-nucleotidases and channeling of the generated adenosine to adenosines A1 receptors.