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Inherited disorder of purine metabolism. Correlation between central nervous system dysfunction and biochemical defects.
Children with an X-linked neurological disease often classed as cerebral palsy show an absence of an enzyme of purine metabolism, hypoxanthine-guanine phosphoribosyltransferase (PRTase), in the… Expand
Hypoxanthine-guanine phosphoribosyltransferase deficiency in gout.
- W. Kelley, M. Greene, F. Rosenbloom, J. Henderson, J. Seegmiller
- Annals of internal medicine
Excerpt INTRODUCTION Sophisticated biochemical studies in recent years have revealed that the regulation of intracellular metabolism is a logical, orderly, and intricate process. Control of enzyme ...
Morphogenesis of nuclear polyhedrosis virus under conditions of prolonged passage in vitro.
- E. Mackinnon, J. Henderson, D. Stoltz, P. Faulkner
- Biology, Medicine
- Journal of ultrastructure research
- 1 December 1974
An ultrastructural description is given of nuclear polyhedrosis virus (NPV) morphogenesis in vitro, with emphasis on changes occurring during long-term serial passage of infectious material. The… Expand
Care for Amish and Mennonite children with cystic fibrosis: a case series
BackgroundPublished articles have described a lack of willingness to allow preventative measures, as well as other types of modern therapies, as an obstacle to providing medical care for Amish and… Expand
A specific enzyme defect in gout associated with overproduction of uric acid.
- W. Kelley, F. Rosenbloom, J. Henderson, J. Seegmiller
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 June 1967
Gout is classed among the inborn errors of metabolism,1 but unlike the majority of such disorders no single specific metabolic defect has yet been found to account for the hyperuricemia… Expand
Quantitative analysis of purine and pyrimidine metabolism in Chinese hamster ovary cells.
- D. Hunting, J. Hordern, J. Henderson
- Chemistry, Medicine
- Canadian journal of biochemistry
- 1 October 1981
A detailed quantitative study of purine and pyrimidine metabolism in logarithmically growing Chinese hamster ovary cells has been performed. Direct measurements of the ribonucleoside and… Expand
Consequences of inhibition of guanine nucleotide synthesis by mycophenolic acid and virazole.
Mycophenolic acid and virazole are inhibitors of inosinate dehydrogenase and produce growth inhibition and loss of viability in cultured murine lymphoma L5178Y cells. Treatment with 1 muM… Expand
LYON HYPOTHESIS AND X-LINKED DISEASE
Compartmentation of intracellular nucleotides in mammalian cells.
The important role of nucleotides in cellular metabolism requires that serious consideration be given to the question of the homogeneity or inhomogeneity of nucleotide pools in cells. The purpose of… Expand
Intracellular differentiation of purine ribonucleotides derived from endogenous and exogenous sources.
Abstract Ethidium bromide inhibits completely the incorporation of adenine, guanine and hypoxanthine into nucleic acids of Ehrlich ascites tumor cells in vitro . It inhibits the incorporation of… Expand