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Inherited disorder of purine metabolism. Correlation between central nervous system dysfunction and biochemical defects.
Children with an X-linked neurological disease often classed as cerebral palsy show an absence of an enzyme of purine metabolism, hypoxanthine-guanine phosphoribosyltransferase (PRTase), in theExpand
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Hypoxanthine-guanine phosphoribosyltransferase deficiency in gout.
Excerpt INTRODUCTION Sophisticated biochemical studies in recent years have revealed that the regulation of intracellular metabolism is a logical, orderly, and intricate process. Control of enzyme ...
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Morphogenesis of nuclear polyhedrosis virus under conditions of prolonged passage in vitro.
An ultrastructural description is given of nuclear polyhedrosis virus (NPV) morphogenesis in vitro, with emphasis on changes occurring during long-term serial passage of infectious material. TheExpand
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Care for Amish and Mennonite children with cystic fibrosis: a case series
BackgroundPublished articles have described a lack of willingness to allow preventative measures, as well as other types of modern therapies, as an obstacle to providing medical care for Amish andExpand
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A specific enzyme defect in gout associated with overproduction of uric acid.
Gout is classed among the inborn errors of metabolism,1 but unlike the majority of such disorders no single specific metabolic defect has yet been found to account for the hyperuricemiaExpand
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Quantitative analysis of purine and pyrimidine metabolism in Chinese hamster ovary cells.
A detailed quantitative study of purine and pyrimidine metabolism in logarithmically growing Chinese hamster ovary cells has been performed. Direct measurements of the ribonucleoside andExpand
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Consequences of inhibition of guanine nucleotide synthesis by mycophenolic acid and virazole.
Mycophenolic acid and virazole are inhibitors of inosinate dehydrogenase and produce growth inhibition and loss of viability in cultured murine lymphoma L5178Y cells. Treatment with 1 muMExpand
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Compartmentation of intracellular nucleotides in mammalian cells.
The important role of nucleotides in cellular metabolism requires that serious consideration be given to the question of the homogeneity or inhomogeneity of nucleotide pools in cells. The purpose ofExpand
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Intracellular differentiation of purine ribonucleotides derived from endogenous and exogenous sources.
Abstract Ethidium bromide inhibits completely the incorporation of adenine, guanine and hypoxanthine into nucleic acids of Ehrlich ascites tumor cells in vitro . It inhibits the incorporation ofExpand
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