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CYP2D6*4 Allele

Known as: CYP2D6, g.1846G>A, Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*4 Allele, CYP2D6(B) 
Human CYP2D6*4 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type… 
National Institutes of Health

Related topics

Related topics

12 relations
22q13.1Guanosine to Adenosine Transition AbnormalityInactive - Biochemical Activity LevelIron Chelation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
1998
Review
1998
P450 enzymes and Parkinson's disease: The story so far
Environmental or endogenous toxins may cause nigral cell death in Parkinson's disease (PD) as a result of genetic susceptibility… 
Highly Cited
1996
Highly Cited
1996
Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis.
OBJECTIVES--To determine whether particular genotypes for the cytochrome P450 enzyme CYP2D6, a polymorphic enzyme, are associated… 
Highly Cited
1996
Highly Cited
1996
Phenotype and genotype analysis of debrisoquine hydroxylase (CYP2D6) in a black Zimbabwean population Reduced enzyme activity and evaluation of metabolic correlation of CYP2D6 probe drugs
Objective: Debrisoquine hydroxylase (CYP2D6) is responsible for the oxidative metabolism of many clinically used drugs. Since… 
Highly Cited
1995
Highly Cited
1995
Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.
Hydroxylation of debrisoquine, catalyzed by the cytochrome P450 CYP2D6 exhibits genetic polymorphism, with large inter-individual… 
Review
1995
Review
1995
Geographical/Interracial Differences in Polymorphic Drug Oxidation
SummaryThe isoenzymes which catalyse the polymorphic hydroxylations of debrisoquine/sparteine and S-mephenytoin are cytochromes… 
Highly Cited
1995
Highly Cited
1995
Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects.
The CYP2D6 genotype and the debrisoquine and mephenytoin hydroxylation phenotypes were studied in 63 Oriental subjects including… 
Highly Cited
1993
Highly Cited
1993
Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.
A group of Japanese subjects were phenotyped for CYP2D6 activity by administration of sparteine and determination of urine… 
Highly Cited
1993
Highly Cited
1993
Genetic polymorphism of cytochrome P450 CYP2D6 in Zimbabwean population.
The objective of this study was to determine the CYP2D6 genotype of a black Zimbabwean population. Genotyping was carried out… 
Highly Cited
1992
Highly Cited
1992
Mutant debrisoquine hydroxylation genes in Parkinson's disease
Highly Cited
1992
Highly Cited
1992
Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population
The molecular basis of polymorphic debrisoquin hydroxylation was studied in 223 Swedish white subjects, 187 extensive… 
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