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  • Influence
Extrapyramidal reactions with metoclopramide.
The epidemiology of extrapyramidal reactions to metoclopramide was studied by examining reports in the Adverse Reactions Register of the Committee on the Safety of Medicines and comparing these withExpand
Attitudes to adverse drug reaction reporting in the Northern Region.
Most differences within doctor groups were found for junior doctors, with those from low reporting districts indicating they had sent significantly less yellow cards than those in high reporting districts, and significant differences in the estimates junior doctors made with a frequency of adverse drug reactions. Expand
Measurement of gastric emptying by real-time ultrasound.
Ultrasound measurement of gastric emptying provides an opportunity to study the effects of drugs and disease on gastric motor function in man. Expand
Congenital anomalies after prenatal ecstasy exposure
Prospective follow-up of 136 babies exposed to ecstasy in utero indicated that the drug may be associated with a significantly increased risk of congenital defects (15.4% [95% CI 8.2-25.4]).Expand
Paracetamol toxicity: epidemiology, prevention and costs to the health-care system.
The use, abuse and ways of reducing paracetamol toxicity are reviewed, but in view of the potential for harm, serious consideration should be given to changing the legal status of paracetAMol, possibly to a prescription-only medicine. Expand
Prazosin, pharmacokinetics and concentration effect
The effects of prazosin on blood pressure were more pronounced after intravenous than oral administration, and the hypotensive effect greater on erect blood pressure, and there was a significant correlation (P<0.02) between the fall in blood pressure and the plasma drug concentration after intravenously prazoin. Expand
Clinical Pharmacokinetics of Metoclopramide
  • D. Bateman
  • Medicine
  • Clinical pharmacokinetics
  • 1 November 1983
Preliminary studies after ‘high dose’ metoclopramide demonstrate accumulation to high plasma concentrations with linear kinetics, suggesting that current high dose regimens are unnecessarily cumbersome. Expand
Presentation of poisoned patients to accident and emergency departments in the North of England
The study illustrates the frequency of presentations of poisoning to A&E departments in young men and the increasing use of paracetamol are particular causes for concern. Expand
The pharmacokinetics of metoclopramide in man with observations in the dog.
In the dog the metabolic fate of metoclopramide is different to man with conjugation being a minor metabolic pathway and the half-life in the dog does not appear to be dose dependent. Expand
Extrapyramidal reactions to metoclopramide and prochlorperazine.
The incidence of extrapyramidal events amongst patients receiving 'first' prescriptions for metoclopramide and prochlorperazine from general practitioners in the Northern Region using community pharmacists to capture prescriptions was significantly greater in those under 30 years than in those 30 years and over. Expand