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Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.
Important interethnic differences exist in the structure of the CYP2D locus, and they suggest that the frequent distribution of the C188-->T mutation among the CYp2D6Ch genes explains the lower capacity among Chinese to metabolize drugs that are substrates of CYP 2D6, such as antidepressants and neuroleptic agents. Expand
Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism.
The data indicate that CYP3A4, CYp3A5, CYP 3A43, and PXR hepatic mRNA expression correlate, indicating common regulatory features, and that the contribution of CYP2A5 to hepatic drug metabolism in Caucasians is insignificant. Expand
Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.
Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as phenytoin, S-warfarin, tolbutamide, losartan, torasemide, and nonsteroidal anti-inflammatory drugs. A functionalExpand
Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43.
It is concluded that CYP3A43 mRNA is expressed mainly in liver and testis and that the protein would not contribute significantly to human drug metabolism. Expand
Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles.
The Ethiopian population, in comparison to Caucasian, Oriental and other Black populations, is genetically different with respect to the constitution of the CYP2D locus, implicating this issue of potential global importance. Expand
Cytochrome P450 2D6 genotype and steady state plasma levels of risperidone and 9-hydroxyrisperidone
It is indicated that the CYP2D6 polymorphism may be of limited importance for the clinical outcome of the treatment of schizophrenic patients on monotherapy with risperidone, and the lack of relationship between the genotype and the sum of ris peridone and 9-OH-risperidones indicates that the cytochrome P450 2D6 genotype is oflimited importance. Expand
Genetic polymorphism of xenobiotic metabolizing enzymes among Chinese lung cancer patients
The results indicate that the polymorphisms investigated are of minor importance as genetic susceptibility markers for lung cancer in this population and suggests that polymorphism in this gene might possibly be a susceptibility factor in the Chinese population. Expand
Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1.
CYP2W1 represents a tumor-specific P450 isoform with potential importance as a drug target in cancer therapy and was seen following demethylation by 5-Aza-2'-deoxycytidine. Expand
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.
The data show the principle of inherited amplification of an active gene, and the finding of a specific haplotype with two or more active CYP2D6 genes allows genotyping for ultrarapid drug metabolizers. Expand
Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.
A haplotype with duplicated or amplified functional CYP2D6 genes predicts, with high accuracy, ultrarapid metabolism of debrisoquine. Expand