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CYP2C19 protein, human

Known as: P450-254C, P4502C19, human, mephenytoin hydroxylase, human 
Cytochrome P450 2C19 (490 aa, ~56 kDa) is encoded by the human CYP2C19 gene. This protein is involved in steroid, terpenoid and drug metabolism.
National Institutes of Health

Related topics

Related topics

47 relations
AmitriptylineAmitriptyline HydrochlorideArachidonic Acid Metabolism PathwayAromatase

Broader (3)

Aryl Hydrocarbon HydroxylasesCytochrome P-450 CYP2C19Xenobiotic Monooxygenases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Effect of bacterial and host factors on Helicobacter pylori eradication therapy
Introduction: A clearer understanding of the factors affecting the cure rate of Helicobacter pylori infection might lead to the… 
Review
2011
Review
2011
Intravenous proton pump inhibitors for peptic ulcer bleeding: Clinical benefits and limits.
Peptic ulcer bleeding is a common disease and recurrent bleeding is an independent risk factor of mortality. Infusion with proton… 
Highly Cited
2004
Highly Cited
2004
Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man
SummaryInherited deficiency in mephenytoin hydroxylation was observed in a family study. It is important that the propositus was… 
Highly Cited
2001
Highly Cited
2001
Metabolic characterization of the major human small intestinal cytochrome p450s.
Human small intestine epithelial cells (enterocytes) provide the first site for cytochrome P450 (CYP)-catalyzed metabolism of… 
Highly Cited
1991
Highly Cited
1991
Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.
Purification and immunoinhibition studies have suggested that the hydroxylations of (S)-mephenytoin and tolbutamide are catalyzed… 
Highly Cited
1988
Highly Cited
1988
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
A cytochrome P-450 (P-450) multigene family codes for several related human liver enzymes, including the P-450 responsible for (S… 
1988
1988
Mephenytoin hydroxylation in the Cuna Amerindians of Panama.
1 Mephenytoin p(4')-hydroxylation, which is deficient in 3-5% of Caucasians, was examined in 96 Cuna Amerindians of Panama. 2… 
1986
1986
Family studies of mephenytoin hydroxylation deficiency.
A genetic polymorphism characterized by deficient drug oxidation exists for the hydroxylation of mephenytoin. This deficiency was… 
Highly Cited
1985
Highly Cited
1985
Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation
The 8‐hour urinary recovery of 4‐hydroxy‐mephobarbital has been measured after oral administration of racemic mephobarbital (90… 
Highly Cited
1984
Highly Cited
1984
Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism
The ability of normal subjects to hydroxylate mephenytoin (100 mg) or debrisoquine (10 mg) after oral dosing was investigated in… 
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