Cytochrome P450
- W. Backes, Benveniste, G. Strobl
- ChemistryHandbook of Experimental Pharmacology
- 1993
It is shown that in allylic hydroxyl ations (catalyzed by either model metalloporphyrins or cytochrome P450) rehydridization could occur to yield multiple products.
Human P450 metabolism of warfarin.
- L. Kaminsky, Z. Zhang
- Chemistry, BiologyPharmacology and Therapeutics
- 1997
Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts.
- Xinxin Ding, L. Kaminsky
- Medicine, BiologyAnnual Review of Pharmacology and Toxicology
- 28 November 2003
Of particular interest are the preferential expression of certain CYPs in the respiratory tract and the regional differences in CYP expression profile in different parts of the gastrointestinal tract.
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism.
- T. Sullivan-Klose, B. Ghanayem, J. Goldstein
- BiologyPharmacogenetics (London)
- 1 August 1996
The present data suggest that the incidence of the Leu359 allelic variant of CYP2C9 may account for the occurrence of poor metabolizers of tolbutamide.
Characterization of human small intestinal cytochromes P-450.
- Q. Y. Zhang, D. Dunbar, A. Ostrowska, S. Zeisloft, J. Yang, L. Kaminsky
- Biology, MedicineDrug Metabolism And Disposition
- 1 July 1999
CYP3A4 is the major form of CYP expressed in human small intestine enterocytes, while CYP3A5 expression was not detected, CYP2C and, in some intestines, CyP1A1 were expressed and the highest metabolic activity occurred in the proximal intestine.
The small intestine as a xenobiotic-metabolizing organ.
- L. Kaminsky, Qing-Yu Zhang
- BiologyDrug Metabolism And Disposition
- 1 December 2003
The mammalian small intestine serves principally as the site for absorption of nutrients, water, and both beneficial and potentially harmful xenobiotics, but it has become apparent over the past 20 years that an array of metabolic machinery is also involved.
Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures.
- D. Vakharia, N. Liu, L. Kaminsky
- BiologyToxicology and Applied Pharmacology
- 15 January 2001
The metals in PAH/metal mixtures could diminish PAH carcinogenicity by decreasing induction of their bioactivation by CYP1A1/1A2.
Human cytochromes P450
- J. Hasler, R. Estabrook, P. Beaune
- Biology
- 1 February 1999
Optimization of Dnase I removal of contaminating DNA from RNA for use in quantitative RNA-PCR.
- Z. Huang, M. Fasco, L. Kaminsky
- BiologyBioTechniques
- 1 June 1996
This investigation was undertaken to optimize DNase I treatment of RNA with respect to DNA removal and mRNA preservation and found that incubation of 1 microgram RNA with 1 U of DNase for 30 min at 37 degrees C followed by heat-denaturation of the enzyme for 5 min at 75 degrees C was sufficient to destroy all the contaminating DNA, while completely preserving the respective mRNAs.
Expression of cytochromes P450 in human breast tissue and tumors.
- Z. Huang, M. Fasco, H. Figge, K. Keyomarsi, L. Kaminsky
- Biology, MedicineDrug Metabolism And Disposition
- 1 August 1996
Examples of each of the xenobiotic-metabolizing CYP1, CYP2, and CYP3 subfamilies were detected in low levels in human normal breast tissue and tumors, indicating the machinery for possible in situ bioactivation of xenobiotics and modification of therapeutic drugs is thus present in human breast tissue.
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