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Traces of Human Migrations in Helicobacter pylori Populations
Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations deriveExpand
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
Adenovirus mediated gene transfer of wild-type AXIN1 induced apoptosis in hepatocellular and colorectal cancer cells that had accumulated β-catenin as a consequence of either APC, CTNNB1 orAXIN1 mutation, suggesting that axin may be an effective therapeutic molecule for suppressing growth of hepato cellular andcolorectAL cancers. Expand
An African origin for the intimate association between humans and Helicobacter pylori
It is established that anatomically modern humans were already infected by H. pylori before their migrations from Africa and demonstrate that H.pylori has remained intimately associated with their human host populations ever since. Expand
Relationship between Helicobacter pylori iceA, cagA, and vacA Status and Clinical Outcome: Studies in Four Different Countries
IceA status shows considerable geographic differences, and neither iceA nor combinations of iceA, vacA, andcagA were helpful in predicting the clinical presentation of an H. pylori infection. Expand
Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma
The high incidence of occult vascular invasion and advanced histologic grade in HCC tumors larger than 5 cm, as well as biologic predictors of poor prognosis, should be considered before criteria for transplantation are expanded to include these patients. Expand
Mechanisms of disease: Helicobacter pylori virulence factors
  • Y. Yamaoka
  • Medicine
  • Nature Reviews Gastroenterology &Hepatology
  • 1 November 2010
Despite advances in understanding of the development of H. pylori-related diseases, further work is required to clarify the roles ofH. Expand
Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients.
TACE showed safe therapeutic modality with a 5-year survival of 26% for unresectable HCC patients and both the degree of liver damage and the tumor-node-metastasis (TNM) system proposed by the Liver Cancer Study Group of Japan demonstrated good stratification of survivals. Expand
Staging of Hepatocellular Carcinoma: Assessment of the Japanese TNM and AJCC/UICC TNM Systems in a Cohort of 13,772 Patients in Japan
The findings support the development of LCSG stage, and while both staging systems allow for the clear stratification of patients into prognostic groups, the LCSGJ staging may be more appropriate for stratifying patients with early-stage HCC. Expand
Reevaluation of prognostic factors for survival after liver resection in patients with hepatocellular carcinoma in a Japanese nationwide survey
Advances in the diagnosis and surgical treatment of hepatocellular carcinoma have improved the prognosis for patients with HCC who undergo liver resection, and a nationwide data base was evaluated to evaluate prognostic predictors. Expand
Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression.
Examination of expression profiles of 20 primary HCCs and their corresponding noncancerous tissues by means of cDNA microarrays identified a number of genes associated with malignant histological type or invasive phenotype that will make it possible to define the nature of individual tumors. Expand