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CUL1 gene

Known as: CUL1, CULLIN 1, Cullin 1 Gene 
This gene plays a role in protein degradation and the negative regulation of cell proliferation.
National Institutes of Health

Related topics

Related topics

3 relations
Cullin 1Protein Degradation, RegulatoryUbiquitination

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.
Abnormal centrosome and centriole numbers are frequently detected in tumor cells where they can contribute to mitotic aberrations… 
Highly Cited
2008
Highly Cited
2008
Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail
SCF (Skp1·CUL1·F-box protein·ROC1) E3 ubiquitin ligase and Cdc34 E2-conjugating enzyme catalyze polyubiquitination in a precisely… 
Highly Cited
2006
Highly Cited
2006
Fbxw8 Is Essential for Cul1-Cul7 Complex Formation and for Placental Development
ABSTRACT Cullin-based ubiquitin ligases (E3s) constitute one of the largest E3 families. Fbxw8 (also known as Fbw6 or Fbx29) is… 
Highly Cited
2003
Highly Cited
2003
Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis
The AXR6 gene is required for auxin signaling in the Arabidopsis embryo and during postembryonic development. One of the effects… 
Highly Cited
2003
Highly Cited
2003
Nedd8-modification of Cul1 is promoted by Roc1 as a Nedd8-E3 ligase and regulates its stability.
Highly Cited
2002
Highly Cited
2002
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
Highly Cited
2001
Highly Cited
2001
Promotion of NEDD8-CUL1 Conjugate Cleavage by COP9 Signalosome
SCF ubiquitin ligases control various processes by marking regulatory proteins for ubiquitin-dependent proteolysis. To illuminate… 
Highly Cited
2001
Highly Cited
2001
The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p
BackgroundThe function of the fission yeast cullins Pcu1p and Pcu4p requires modification by the ubiquitin-related peptide Ned8p… 
Highly Cited
2000
Highly Cited
2000
The CUL1 C-Terminal Sequence and ROC1 Are Required for Efficient Nuclear Accumulation, NEDD8 Modification, and Ubiquitin Ligase Activity of CUL1
ABSTRACT Members of the cullin and RING finger ROC protein families form heterodimeric complexes to constitute a potentially… 
Highly Cited
1999
Highly Cited
1999
Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha.
Activation of the transcription factor NF-kappa B in response to proinflammatory stimuli requires the phosphorylation-triggered… 
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