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A Plant miRNA Contributes to Antibacterial Resistance by Repressing Auxin Signaling
It is shown that a flagellin-derived peptide induces a plant microRNA (miRNA) that negatively regulates messenger RNAs for the F-box auxin receptors TIR1, AFB2, and AFB3, implicating auxin in disease susceptibility and miRNA-mediated suppression of auxin signaling in resistance. Expand
The F-box protein TIR1 is an auxin receptor
TIR1 is an auxin receptor that mediates Aux/IAA degradation and auxin-regulated transcription and the loss of TIR1 and three related F-box proteins eliminates saturable auxin binding in plant extracts. Expand
Auxin regulates SCFTIR1-dependent degradation of AUX/IAA proteins
It is shown that SCFTIR1 is required for AUX/IAA degradation, and it is proposed that auxin promotes the degradation of this large family of transcriptional regulators, leading to diverse downstream effects. Expand
Plant development is regulated by a family of auxin receptor F box proteins.
It is shown that three additional F box proteins, called AFB1, 2, and 3, also regulate auxin response and collectively mediate auxin responses throughout plant development. Expand
Mechanism of auxin perception by the TIR1 ubiquitin ligase
These structures show that the leucine-rich repeat domain of TIR1 contains an unexpected inositol hexakisphosphate co-factor and recognizes auxin and the Aux/IAA polypeptide substrate through a single surface pocket, establishing the first structural model of a plant hormone receptor. Expand
The Physcomitrella Genome Reveals Evolutionary Insights into the Conquest of Land by Plants
This comparison reveals genomic changes concomitant with the evolutionary movement to land, including a general increase in gene family complexity; loss of genes associated with aquatic environments; acquisition of genes for tolerating terrestrial stresses; and the development of the auxin and abscisic acid signaling pathways for coordinating multicellular growth and dehydration response. Expand
The TIR1 protein of Arabidopsis functions in auxin response and is related to human SKP2 and yeast grr1p.
- M. Ruegger, E. Dewey, W. Gray, L. Hobbie, J. Turner, M. Estelle
- Biology, Medicine
- Genes & development
- 15 January 1998
The identification of a new gene called TRANSPORT InhIBITor RESPONSE 1 (TIR1), which contains a series of leucine-rich repeats and a recently identified motif called an F box, indicates that TIR1 is also required for normal response to auxin. Expand
Insensitivity to Ethylene Conferred by a Dominant Mutation in Arabidopsis thaliana
Results of ethylene binding experiments in vivo indicate that this receptor may be affected by the etr mutation, and this receptor appears to share some common element in their transduction pathways—for example, a single receptor for ethylene. Expand
Growth and development of the axr1 mutants of Arabidopsis.
It is suggested that the AXR1 gene is required for auxin action in most, if not all, tissues of the plant and plays an important role in plant development. Expand
Identification of an SCF ubiquitin-ligase complex required for auxin response in Arabidopsis thaliana.
In Arabidopsis, auxin response is dependent on a ubiquitin-ligase (E3) complex called SCFTIR1, which provides new support for a model in which auxin action depends on the regulated proteolysis of repressor proteins. Expand