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Cullin 1

Known as: CUL-1, Cullin Homolog 1, Cullin-1 
Cullin-1 (776 aa, ~90 kDa) is encoded by the human CUL1 gene. This protein plays a role in protein ubiquitination and cell cycle regulation.
National Institutes of Health

Related topics

Related topics

16 relations
CUL1 geneCanonical Wnt Signaling PathwayCullin Family ProteinE2F1 Degradation Pathway

Narrower (3)

CUL1 protein, ArabidopsisCUL1 protein, humanCul-1 protein, C elegans

Broader (1)

Cullin Proteins

Papers overview

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2018
2018
Structural basis for Cullins and RING component inhibition: Targeting E3 ubiquitin pathway conductors for cancer therapeutics.
2012
2012
The Arabidopsis F-box protein AtFBS1 interacts with 14-3-3 proteins.
2011
2011
Regulation of Cullin RING E3 Ubiquitin Ligases by CAND1 In Vivo
Cullin RING ligases are multi-subunit complexes consisting of a cullin protein which forms a scaffold onto which the RING protein… 
2010
2010
Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization
F-box proteins are the substrate recognition subunits of SCF (Skp1, Cul1, F-box protein) ubiquitin ligase complexes. Skp2 is a… 
2010
2010
Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2
Skp2 is the substrate binding subunit of the SCFSkp2 ubiquitin ligase, which plays a key role in the regulation of cell cycle… 
2008
2008
Involvement of two distinct ubiquitin E3 ligase systems for p27 degradation in corneal endothelial cells.
PURPOSE p27(Kip1) (p27) is an important regulator of G(1) progression. For cells to proliferate, p27 must undergo proteolysis… 
2007
2007
Regulation of SCFSKP2 Ubiquitin E3 Ligase Assembly and p27KIP1 Proteolysis by the PTEN Pathway and Cyclin D1
The PTEN tumor suppressor functions as a phosphatase of phosphatidylinositol 3,4,5-trisphosphate (PIP3) and negatively regulates… 
2004
2004
Differential regulation of components of the ubiquitin-proteasome pathway during lens cell differentiation.
PURPOSE To investigate the role for the ubiquitin-proteasome pathway in controlling lens cell proliferation and differentiation… 
2003
2003
Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during Drosophila oogenesis
Exit from the cell cycle requires the downregulation of Cyclin/Cdk activity. In the ovary of Drosophila, Encore activity is… 
2003
2003
Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila
BackgroundCul1 is a core component of the evolutionarily conserved SCF-type ubiquitin ligases that target specific proteins for… 
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