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Cullin 1

Known as: CUL-1, Cullin Homolog 1, Cullin-1 
Cullin-1 (776 aa, ~90 kDa) is encoded by the human CUL1 gene. This protein plays a role in protein ubiquitination and cell cycle regulation.
National Institutes of Health

Related topics

Related topics

16 relations
CUL1 geneCanonical Wnt Signaling PathwayCullin Family ProteinE2F1 Degradation Pathway

Narrower (3)

CUL1 protein, ArabidopsisCUL1 protein, humanCul-1 protein, C elegans

Broader (1)

Cullin Proteins

Papers overview

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Highly Cited
2007
Highly Cited
2007
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex
The proteasome maintains cellular homeostasis by degrading oxidized and damaged proteins, a function known to be impaired during… 
Highly Cited
2003
Highly Cited
2003
Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis.
Ubiquitin E3 ligases are a diverse family of protein complexes that mediate the ubiquitination and subsequent proteolytic… 
Highly Cited
2003
Highly Cited
2003
The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis
The related‐to‐ubiquitin (RUB) protein is post‐translationally conjugated to the cullin subunit of the SCF (SKP1, Cullin, F‐box… 
Highly Cited
2003
Highly Cited
2003
Arabidopsis AXR6 encodes CUL1 implicating SCF E3 ligases in auxin regulation of embryogenesis
The AXR6 gene is required for auxin signaling in the Arabidopsis embryo and during postembryonic development. One of the effects… 
Highly Cited
2002
Highly Cited
2002
Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1
COP9 signalosome (CSN) cleaves the ubiquitin-like protein Nedd8 from the Cul1 subunit of SCF ubiquitin ligases. The Jab1/MPN… 
Highly Cited
2002
Highly Cited
2002
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
Highly Cited
2002
Highly Cited
2002
Dual mode of degradation of Cdc25 A phosphatase
The Cdc25 dual‐specificity phosphatases control progression through the eukaryotic cell division cycle by activating cyclin… 
Highly Cited
2002
Highly Cited
2002
Role of the Arabidopsis RING-H2 Protein RBX1 in RUB Modification and SCF Function Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.003178.
The ubiquitin-related protein RUB/Nedd8 is conjugated to members of the cullin family of proteins in plants, animals, and fungi… 
Highly Cited
2000
Highly Cited
2000
The F‐box protein Skp2 is a ubiquitylation target of a Cul1‐based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts
The ubiquitin protein ligase SCFSkp2 is composed of Skp1, Cul1, Roc1/Rbx1 and the F‐box protein Skp2, the substrate‐recognition… 
Highly Cited
1999
Highly Cited
1999
Identification of a family of human F-box proteins
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