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Canonical Wnt Signaling Pathway

Known as: Wnt receptor signaling pathway through beta-catenin, canonical Wnt-activated signaling pathway, Wnt receptor signalling pathway through beta-catenin 
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by… 
National Institutes of Health

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Related topics

18 relations
APC protein, humanAPC wt AlleleCAV1 protein, humanCAV1 wt Allele

Narrower (5)

canonical Wnt signaling pathway involved in mesonephric nephron developmentcanonical Wnt signaling pathway involved in mesonephros developmentcanonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiationcanonical Wnt signaling pathway involved in osteoblast differentiation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Interplay of miRNAs and Canonical Wnt Signaling Pathway in Hepatocellular Carcinoma
Hepatocellular carcinoma is one of the leading causes of cancer death worldwide and the activation of canonical Wnt signaling… 
2016
2016
MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway
Wnt/β-catenin signaling pathway plays essential roles in mammalian development and tissue homeostasis. MicroRNAs (miRNAs) are a… 
2013
2013
Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway
Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer and is… 
2013
2013
Coordinate regulation of N-glycosylation gene DPAGT1, canonical Wnt signaling and E-cadherin adhesion
Summary The metabolic pathway of protein N-glycosylation influences intercellular adhesion by affecting the composition and… 
Highly Cited
2012
Highly Cited
2012
Existence of the canonical Wnt signaling pathway in the human trabecular meshwork.
PURPOSE We previously discovered elevated levels of secreted frizzled-related protein 1 (sFRP1), the Wnt signaling pathway… 
2012
2012
Wnt3a stimulates Mepe, Matrix extracellular phosphoglycoprotein, expression directly by the activation of the canonical Wnt signaling pathway and indirectly through the stimulation of autocrine Bmp‐2…
Matrix extracellular phosphoglycoprotein (MEPE) is a specific marker of mineralizing osteoblasts and osteocytes. Canonical BMP… 
2011
2011
Silencing of CXCR4 Blocks Progression of Ovarian Cancer and Depresses Canonical Wnt Signaling Pathway
Objective: CXC chemokine receptor 4 (CXCR4) was considered to be an important factor in cancer cell metastasis. This study was… 
Review
2010
Review
2010
Non-canonical Wnt signaling pathways in hematopoiesis
Hematopoietic stem cells (HSCs) are a rare population of cells that are responsible for life-long generation of blood cells of… 
Review
2008
Review
2008
Tissue-specific transgenic, conditional knockout and knock-in mice of genes in the canonical Wnt signaling pathway.
The Wnt signaling pathway plays key roles in the development and homeostasis of a number of organs such as the brain, lung, liver… 
Highly Cited
2004
Highly Cited
2004
The Low Density Lipoprotein Receptor-1, LRP1, Interacts with the Human Frizzled-1 (HFz1) and Down-regulates the Canonical Wnt Signaling Pathway*
Members of the low density lipoprotein receptor family (LDLR), LRP5/6, were shown to interact with the Frizzled (Fz) receptors… 
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