Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway

  title={Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway},
  author={Nir Skalka and Michal Caspi and Elanite Caspi and Y. Peng Loh and Rina Rosin-Arbesfeld},
Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including cancer and is especially implicated in the development and progression of colorectal cancer. The key effector protein of the canonical Wnt pathway is β-catenin, which functions with T-cell factor/lymphoid enhancer factor to activate expression of Wnt target genes. In this study, we used a new functional screen based on cell survival in the presence of cDNAs encoding proteins that activate… CONTINUE READING
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An N-terminal truncated carboxypeptidase E splice isoform induces metastasis by activating NEDD9 and other metastasis inducing genes

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  • AACR Annual Meeting
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