A. Clark

Publications463
h-index63
Citations12,541
Highly Influential Citations588
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Identification of a Gene That Causes Primary Open Angle Glaucoma
Glaucoma is a major cause of blindness and is characterized by progressive degeneration of the optic nerve and is usually associated with elevated intraocular pressure. Analyses of sequence tagged… Expand
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Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration.
The glaucomas are neurodegenerative diseases involving death of retinal ganglion cells and optic nerve head excavation. A major risk factor for this neurodegeneration is a harmfully elevated… Expand
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Characterization of a transformed rat retinal ganglion cell line.
The purpose of the present study was to establish a rat retinal ganglion cell line by transformation of rat retinal cells. For this investigation, retinal cells were isolated from postnatal day 1… Expand
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Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.
Glaucoma is one of the most common neurodegenerative diseases. Despite this, the earliest stages of this complex disease are still unclear. This study was specifically designed to identify early… Expand
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TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure.
PURPOSE Transforming growth factor (TGF)-beta2 levels are elevated in glaucomatous human aqueous humor. TGFbeta is a cytokine that alters extracellular matrix (ECM) metabolism, and excess ECM has… Expand
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Non-secretion of mutant proteins of the glaucoma gene myocilin in cultured trabecular meshwork cells and in aqueous humor.
Until recently, very little was known about the molecular mechanisms responsible for the development of glaucoma, a leading cause of blindness worldwide. Mutations in the glaucoma gene myocilin… Expand
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Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma.
Mutations in myocilin (MYOC) are the most common genetic cause of primary open angle glaucoma (POAG), but the mechanisms underlying MYOC-associated glaucoma are not fully understood. Here, we report… Expand
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Glucocorticoid-induced formation of cross-linked actin networks in cultured human trabecular meshwork cells.
PURPOSE To determine the effects of glucocorticoid treatment on the microfilament structure of cultured human trabecular meshwork cells. Topical or systemic administration of glucocorticoids can lead… Expand
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The many faces of the trabecular meshwork cell
ABSTRACT With the combined purpose of facilitating useful vision over a lifetime, a number of ocular cells have evolved specialized features not found elsewhere in the body. The trabecular meshwork… Expand
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Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma.
PURPOSE The primary causative factor of primary open-angle glaucoma (POAG) is elevated intraocular pressure (IOP) due to increased aqueous humor (AH) outflow resistance, which is associated with… Expand
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