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Cullin Proteins

Known as: Cullin Protein, Cullins, Cullin Domain Proteins 
A family of structurally related proteins that were originally discovered for their role in cell-cycle regulation in CAENORHABDITIS ELEGANS. They… 
National Institutes of Health

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Narrower (7)

CACUL1 protein, humanCUL2 protein, humanCdc53 protein, S cerevisiaeCullin 1
In BloodProcess of secretionSKP Cullin F-Box Protein Ligasesagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
CUL4A as a marker and potential therapeutic target in multiple myeloma
Multiple myeloma is the most common cause of death of hematological malignancy worldwide. Cullin 4A has been proposed as oncogene… 
Review
2014
Review
2014
Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis.
2014
2014
Cullins keep autophagy under control.
Review
2014
Review
2014
New insights into the mechanism for VACM-1/cul5 expression in vascular tissue in vivo.
2011
2011
Inhibition of NEDD 8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT 1 Turnover
Loss of NEDD8-activating enzyme (NAE) function by siRNA knockdown or inhibition by the small molecule NAE inhibitor MLN4924 leads… 
2010
2010
Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3-RINGBox1 protein complex and elucidation of its quaternary structure with Keap1.
2007
2007
The Cullin 3 Ubiquitin Ligase Functions as a Nedd 8-bound Heterodimer
Cullins are members of a family of scaffold proteins that assemble multisubunit ubiquitin ligase complexes to confer substrate… 
2005
2005
Recruiting Substrates to Cullin 4-Dependent Ubiquitin Ligases by DDB1
The ubiqutin-proteasome system is the major pathway by which cells target proteins for degradation in a specific manner. The E3… 
2005
2005
Nep1, a Schizosaccharomyces pombe deneddylating enzyme.
Nedd8 is a ubiquitin-like modifier that is attached to the cullin components of E3 ubiquitin ligases. More recently, p53 has also… 
Review
2002
Review
2002
Control of the centriole and centrosome cycles by ubiquitination enzymes
The role of the centriole in organizing the cell’s cytoskeleton and its mechanism of duplication have been long-standing puzzles… 
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