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Cullin Proteins

Known as: Cullin Protein, Cullins, Cullin Domain Proteins 
A family of structurally related proteins that were originally discovered for their role in cell-cycle regulation in CAENORHABDITIS ELEGANS. They… Expand
National Institutes of Health

Papers overview

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Review
2011
Review
2011
SummaryCullin proteins are molecular scaffolds that have crucial roles in the post-translational modification of cellular… Expand
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Highly Cited
2010
Highly Cited
2010
Dynamic reorganization of signaling systems frequently accompanies pathway perturbations, yet quantitative studies of network… Expand
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Highly Cited
2009
Highly Cited
2009
Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin… Expand
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Highly Cited
2005
Highly Cited
2005
The concentrations and functions of many eukaryotic proteins are regulated by the ubiquitin pathway, which consists of ubiquitin… Expand
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Highly Cited
2004
Highly Cited
2004
The SCF ubiquitin ligase complex regulates diverse cellular functions by ubiquitinating numerous protein substrates. Cand1, a 120… Expand
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Highly Cited
2003
Highly Cited
2003
Cullins (CULs) are subunits of a prominent class of RING ubiquitin ligases. Whereas the subunits and substrates of CUL1… Expand
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Highly Cited
2003
Highly Cited
2003
The concentrations and functions of many cellular proteins are regulated by the ubiquitin pathway. Cullin family proteins bind… Expand
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Highly Cited
2003
Highly Cited
2003
Programmed destruction of regulatory proteins through the ubiquitin–proteasome system is a widely used mechanism for controlling… Expand
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Highly Cited
2001
Highly Cited
2001
Although MDM2 plays a major role in regulating the stability of the p53 tumor suppressor protein, other poorly understood MDM2… Expand
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Highly Cited
1999
Highly Cited
1999
We have identified two highly conserved RING finger proteins, ROC1 and ROC2, that are homologous to APC11, a subunit of the… Expand
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