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Cullin Proteins

Known as: Cullin Protein, Cullins, Cullin Domain Proteins 
A family of structurally related proteins that were originally discovered for their role in cell-cycle regulation in CAENORHABDITIS ELEGANS. They… 
National Institutes of Health

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16 relations

Narrower (7)

CACUL1 protein, humanCUL2 protein, humanCdc53 protein, S cerevisiaeCullin 1
In BloodProcess of secretionSKP Cullin F-Box Protein Ligasesagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Structural basis for Cullins and RING component inhibition: Targeting E3 ubiquitin pathway conductors for cancer therapeutics.
Review
2014
Review
2014
Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis.
2014
2014
RSUME inhibits VHL and regulates its tumor suppressor function
Somatic mutations or loss of von Hippel–Lindau (pVHL) happen in the majority of VHL disease tumors, which present a… 
2011
2011
Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site
Cand1 can be separated into two functional polypeptides. C-terminal Cand1 binds first at the cullin adaptor site. N-terminal… 
2011
2011
Regulation of Cullin RING E3 Ubiquitin Ligases by CAND1 In Vivo
Cullin RING ligases are multi-subunit complexes consisting of a cullin protein which forms a scaffold onto which the RING protein… 
2010
2010
C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues.
2010
2010
Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3-RINGBox1 protein complex and elucidation of its quaternary structure with Keap1.
2008
2008
Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome
BackgroundCullin-RING ubiquitin E3 ligases (CRLs) are regulated by modification of an ubiquitin-like protein, Nedd8 (also known… 
Highly Cited
2007
Highly Cited
2007
Structural Basis for the Function of DCN-1 in Protein Neddylation*
Covalent modification by Nedd8 (neddylation) stimulates the ubiquitin-protein isopeptide ligase (E3) activities of Cullins. DCN-1… 
Review
2002
Review
2002
Control of the centriole and centrosome cycles by ubiquitination enzymes
The role of the centriole in organizing the cell’s cytoskeleton and its mechanism of duplication have been long-standing puzzles… 
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