• Publications
  • Influence
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
TLDR
Modulating GLP-1 secretion in gut “taste cells” through the same mechanisms used by taste cells of the tongue may provide an important treatment for obesity, diabetes and abnormal gut motility. Expand
A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway*
TLDR
The cross-regulation of CD36 by PXR and PPARγ suggests that this fatty acid transporter may function as a common target of orphan nuclear receptors in their regulation of lipid homeostasis. Expand
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.
TLDR
The network of CD36 regulation by LXR, PXR, and PPARgamma establishes this free fatty acid transporter as a common target of orphan nuclear receptors in their mediation of lipid homeostasis. Expand
MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation
TLDR
It is reported that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts. Expand
Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases.
TLDR
It is concluded that GSNO-attenuated prolyl hydroxylase activity accounts for HIF-1alpha accumulation under conditions of NO formation during normoxia and that PHD activity is subject to regulation by NO. Expand
Autophagy in cancer associated fibroblasts promotes tumor cell survival
TLDR
A loss of stromal fibroblast Cav-1 is a biomarker for chronic hypoxia, oxidative stress and autophagy in the tumor microenvironment, consistent with its ability to predict early tumor recurrence, lymph node metastasis and tamoxifen-resistance in human breast cancers. Expand
Tumor hypoxia and cancer progression.
TLDR
Understanding the mechanisms by which HIF-1 affects the expression and/or function of key apoptotic regulators such as Bcl-2 family members or p53 will help to uncover how Hif-1 induces cell death and the manner in which cells can overcome such signals and thus determine which of its Janus faces prevail. Expand
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1.
TLDR
CDK8 and CycC function as evolutionarily conserved components of the insulin signaling pathway in regulating lipid homeostasis and are identified as negative regulators of the lipogenic pathway in Drosophila, mammalian hepatocytes, and mouse liver. Expand
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells.
TLDR
It is observed that GLP-1 and exendin-4 induced neurite outgrowth in a manner similar to nerve growth factor (NGF), which was reversed by coincubation with the selective GLp-1 receptor antagonist exENDin (9-39), suggesting that such peptides may be used in reversing or halting the neurodegenerative process observed in neuro degenerative diseases. Expand
PI3K/Akt Is Required for Heat Shock Proteins to Protect Hypoxia-inducible Factor 1α from pVHL-independent Degradation*
TLDR
It is concluded that PI3K/Akt contributes to HIF-1α stabilization by provoking expression of heat shock proteins. Expand
...
1
2
3
4
5
...