Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
- H. Jang, Z. Kokrashvili, J. Egan
- Biology, MedicineProceedings of the National Academy of Sciences
- 18 September 2007
Modulating GLP-1 secretion in gut “taste cells” through the same mechanisms used by taste cells of the tongue may provide an important treatment for obesity, diabetes and abnormal gut motility.
A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway*
- Jie Zhou, Yonggong Zhai, W. Xie
- BiologyJournal of Biological Chemistry
- 26 May 2006
The cross-regulation of CD36 by PXR and PPARγ suggests that this fatty acid transporter may function as a common target of orphan nuclear receptors in their regulation of lipid homeostasis.
MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation
- Xiaorong Zhang, Xinxin Zuo, Xiang-Dong Fu
- BiologyCell
- 31 July 2014
Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis.
- Jie Zhou, M. Febbraio, W. Xie
- Biology, MedicineGastroenterology
- 1 February 2008
The network of CD36 regulation by LXR, PXR, and PPARgamma establishes this free fatty acid transporter as a common target of orphan nuclear receptors in their mediation of lipid homeostasis.
Protein-protein interactions in the regulation of WRKY transcription factors.
- Yingjun Chi, Yan Yang, Zhixiang Chen
- BiologyMolecular Plant
- 1 March 2013
This review summarizes studies of protein-protein interactions for WRKY transcription factors and discusses how the interacting partners contribute, at different levels, to the establishment of the complex regulatory and functional network of WRKYcription factors.
Structural and Functional Analysis of VQ Motif-Containing Proteins in Arabidopsis as Interacting Proteins of WRKY Transcription Factors1[W][OA]
- Yuan Cheng, Yuan Zhou, Zhixiang Chen
- BiologyPlant Physiology
- 24 April 2012
The findings indicate that VQ proteins play an important role in plant growth, development, and response to environmental conditions, most likely by acting as cofactors of group I and IIc WRKY transcription factors.
Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases.
- E. Metzen, Jie Zhou, W. Jelkmann, J. Fandrey, B. Brüne
- BiologyMolecular Biology of the Cell
- 1 August 2003
It is concluded that GSNO-attenuated prolyl hydroxylase activity accounts for HIF-1alpha accumulation under conditions of NO formation during normoxia and that PHD activity is subject to regulation by NO.
Autophagy in cancer associated fibroblasts promotes tumor cell survival
- U. Martinez-outschoorn, C. Trimmer, F. Sotgia
- BiologyCell Cycle
- 1 September 2010
A loss of stromal fibroblast Cav-1 is a biomarker for chronic hypoxia, oxidative stress and autophagy in the tumor microenvironment, consistent with its ability to predict early tumor recurrence, lymph node metastasis and tamoxifen-resistance in human breast cancers.
RNA-seq differential expression studies: more sequence or more replication?
It is shown that sequencing less reads and performing more biological replication is an effective strategy to increase power and accuracy in large-scale differential expression RNA-seq studies, and provided new insights into efficient experiment design of RNA- sequencing studies.
Mechanisms for U2AF to define 3′ splice sites and regulate alternative splicing in the human genome
- C. Shao, Bo Yang, Xiang-Dong Fu
- BiologyNature Structural &Molecular Biology
- 1 November 2014
It is reported that U2AF has the capacity to directly define ~88% of functional 3′ splice sites in the human genome, but numerous U2 AF binding events also occur in intronic locations.
...
...