FAQ

SKP Cullin F-Box Protein Ligases

Known as: Ubiquitin Ligase, SCF, SKP Cullin F-Box Protein Ligases [Chemical/Ingredient], SCF Ubiquitin Ligase 
A subset of ubiquitin protein ligases that are formed by the association of a SKP DOMAIN PROTEIN, a CULLIN DOMAIN PROTEIN and a F-BOX DOMAIN PROTEIN.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2015
01220052015

Related topics

Related topics

12 relations
Cullin ProteinsF-Box ProteinsIn BloodProcess of secretion
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
SKP Cullin F-Box Protein Ligases
physiological aspects
chemical synthesis
standards characteristics
Process of secretion
Cullin Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus
F-box proteins share the F-box domain to connect substrates of E3 SCF ubiquitin RING ligases through the adaptor Skp1/A to Cul1/A… (More)
  • figure 2
  • figure 3
  • figure 7
Is this relevant?
Review
2016
Review
2016
Effectiveness for Long Term Protection
87: Theileria buffeli Infections in Grazing Cattle Located in Mountainous Areas of the Republic of Korea Kyoung-Seong Choi*, Joon… (More)
Is this relevant?
2015
2015
Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus
The Hey protein family, comprising Hey1, Hey2 and HeyL in mammals, conveys Notch signals in many cell types. The helix-loop-helix… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2015
2015
Degradation of GATA2 by Fbw7 1 Regulation of GATA binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of…
A GATA family transcription factor GATA binding protein 2 (GATA2) participates in cell growth and differentiation of various… (More)
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression
Skp2 E3 ligase is overexpressed in numerous human cancers and plays a critical role in cell-cycle progression, senescence… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 6
  • figure 7
Is this relevant?
2011
2011
The Steady-State Repertoire of Human SCF Ubiquitin Ligase Complexes Does Not Require Ongoing Nedd8 Conjugation*
The human genome encodes 69 different F-box proteins (FBPs), each of which can potentially assemble with Skp1-Cul1-RING to serve… (More)
Is this relevant?
2011
2011
The Steady-State Repertoire of Human SCF Ubiquitin Ligase Complexes Does Not Require Ongoing Nedd8 Conjugation*â–¡S
The human genome encodes 69 different F-box proteins (FBPs), each of which can potentially assemble with Skp1Cul1-RING to serve… (More)
  • figure 1
  • figure 2
  • table I
  • table I
  • figure 3
Is this relevant?
Review
2011
Review
2011
Hijacking of the Host SCF Ubiquitin Ligase Machinery by Plant Pathogens
The SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex mediates polyubiquitination of proteins targeted for degradation… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
Is this relevant?
2010
2010
Chronic low frequency/low volume resistance training reduces pro-inflammatory cytokine protein levels and TLR4 mRNA in rat skeletal muscle
Skeletal muscle is the source of pro- and anti-inflammatory cytokines, and recently, it has been recognized as an important… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • table 4
Is this relevant?
2005
2005
[42] Druggability of SCF Ubiquitin Ligase–Protein Interfaces
The unique mechanism of the SCF ubiquitin ligase poses a challenge to drug discovery. A central enzymatic small molecule–binding… (More)
  • table I
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?