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A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
X chromosome-linked inhibitor of apoptosis (XIAP) is an endogenous inhibitor of caspase-3, -7, and -9. Smac/DIABLO, an inhibitor of XIAP, is released from mitochondria upon receiving apoptoticExpand
Plant cells recognize chitin fragments for defense signaling through a plasma membrane receptor.
Chitin is a major component of fungal cell walls and serves as a molecular pattern for the recognition of potential pathogens in the innate immune systems of both plants and animals. In plants,Expand
alpha-Synuclein is phosphorylated in synucleinopathy lesions.
The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. TheseExpand
α-Synuclein is phosphorylated in synucleinopathy lesions
The deposition of the abundant presynaptic brain protein α-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. TheseExpand
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
Xeroderma pigmentosum variant (XP-V) is an inherited disorder which is associated with increased incidence of sunlight-induced skin cancers. Unlike other xeroderma pigmentosum cells (belonging toExpand
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production
Autotaxin (ATX) is a tumor cell motility–stimulating factor, originally isolated from melanoma cell supernatants. ATX had been proposed to mediate its effects through 5′-nucleotide pyrophosphataseExpand
The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein
We have purified and characterized the growth inhibitory factor (GIF) that is abundant in the normal human brain, but greatly reduced in the Alzheimer's disease (AD) brain. GIF inhibited survival andExpand
Activin-binding protein from rat ovary is follistatin.
Activin, a member of the transforming growth factor beta protein family, was originally isolated from gonadal fluids and stimulates the release of pituitary follicle-stimulating hormone (FSH).Expand
Proline-directed and Non-proline-directed Phosphorylation of PHF-tau (*)
To gain insight into the abnormal phosphorylation of PHF-tau, we have determined the phosphorylation sites by identifying phosphopeptides by means of ion spray mass spectrometry followed byExpand
Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch*
The intramembrane cleavage of β-amyloid precursor protein by γ-secretase is the final step in the generation of amyloid β-protein. A 59- or 57-residue C-terminal fragment called CTFγ is producedExpand
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