Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail

@article{Yamoah2008AutoinhibitoryRO,
  title={Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail},
  author={K. Yamoah and T. Oashi and A. Sarikas and S. Gazdoiu and R. Osman and Z. Pan},
  journal={Proceedings of the National Academy of Sciences},
  year={2008},
  volume={105},
  pages={12230 - 12235}
}
  • K. Yamoah, T. Oashi, +3 authors Z. Pan
  • Published 2008
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
SCF (Skp1·CUL1·F-box protein·ROC1) E3 ubiquitin ligase and Cdc34 E2-conjugating enzyme catalyze polyubiquitination in a precisely regulated fashion. Here, we describe biochemical evidence suggesting an autoinhibitory role played by the human CUL1 ECTD (extreme C-terminal domain; spanning the C-terminal 50 amino acids), a region that is predicted to contact the ROC1 RING finger protein by structural studies. We showed that ECTD did not contribute to CUL1's stable association with ROC1… Expand
Mono-ubiquitination Drives Nuclear Export of the Human DCN1-like Protein hDCNL1*
Structural basis for a reciprocal regulation between SCF and CSN.
Neddylation-induced conformational control regulates cullin RING ligase activity in vivo.
Assembly and Regulation of CRL Ubiquitin Ligases.
Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.
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  • S. Gazdoiu, K. Yamoah, +6 authors Z. Pan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
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