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CRKL protein

Known as: CRK-Like Protein, CRKL, Crk-L adaptor 
Crk-like protein (303 aa, ~34 kDa) is encoded by the human CRKL gene. This protein is involved in both protein phosphorylation and signal… 
National Institutes of Health

Related topics

Related topics

19 relations

Broader (2)

Adaptor Proteins, Signal TransducingNuclear Proteins
CRKL geneERBB Family Signaling PathwayErythropoietin Signaling PathwayFocal adhesion pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
The effects of Micro-429 on inhibition of cervical cancer cells through targeting ZEB1 and CRKL.
2013
2013
Overexpression of CRKL correlates with malignant cell proliferation in breast cancer
Crk-like (CRKL) is an adapter protein that has crucial roles in multiple biological processes, including cell proliferation… 
2008
2008
Phospho-CRKL monitoring for the assessment of BCR-ABL activity in imatinib-resistant chronic myeloid leukemia or Ph+ acute lymphoblastic leukemia patients treated with nilotinib
Findings of this study suggest that monitoring the actual BCR-ABL inhibition in nilotinib treated patients may be useful for… 
2001
2001
CrkL Is Recruited through Its SH2 Domain to the Erythropoietin Receptor and Plays a Role in Lyn-mediated Receptor Signaling*
The erythropoietin (Epo) receptor transduces its signals by activating physically associated tyrosine kinases, mainly Jak2 and… 
1999
1999
Identification of a Drosophila homologue to vertebrate Crk by interaction with MBC.
Highly Cited
1998
Highly Cited
1998
Interleukin-2 Stimulation Induces Tyrosine Phosphorylation of p120-Cbl and CrkL and Formation of Multimolecular Signaling Complexes in T Lymphocytes and Natural Killer Cells*
Interleukin (IL)-2, a major growth and differentiation factor for T lymphocytes, was found to induce tyrosine phosphorylation of… 
1997
1997
The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins
The Philadelphia chromosome translocation generates a chimeric oncogene, BCR/ABL, which causes chronic myelogenous leukemia (CML… 
1997
1997
Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells.
The present study demonstrates that erythropoietin (Epo) and IL-3 induce tyrosine phosphorylation of the SH2/SH3-containing… 
1997
1997
Inhibition of Grb2 and Crkl proteins results in growth inhibition of Philadelphia chromosome positive leukemic cells.
The Bcr-Abl oncoprotein is necessary for the growth of Philadelphia chromosome positive (Ph+) leukemic cells. The Bcr-Abl protein… 
1996
1996
Crkl is constitutively tyrosine phosphorylated in platelets from chronic myelogenous leukemia patients and inducibly phosphorylated in normal platelets stimulated by thrombopoietin.
Platelet functions such as aggregation and clot retraction are often abnormal in chronic mylogenous leukemia (CML) patients… 
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