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Erythropoietin Signaling Pathway

Known as: EPO Signaling Pathway 
Erythropoietin functions to increase the number of red blood cells. Thus, it has found utility as a drug for those needing to replenish erythrocytes… Expand
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
Erythropoietin (EPO) plays an important role in the brain's response to neuronal injury. Systemic administration of recombinant… Expand
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Highly Cited
2001
Highly Cited
2001
Erythropoietin (EPO) reduced Ca2+-induced glutamate (Glu) release from cultured cerebellar granule neurons. Inhibition was also… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND We reported recently that normal human, rat, and mouse tubular cells express authentic erythropoietin-receptors (EPO-R… Expand
Highly Cited
1997
Highly Cited
1997
Homodimerization of the erythropoietin (EPO) receptor (EPO-R) in response to EPO binding transiently activates the receptor… Expand
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Review
1997
Review
1997
Red blood cells arise continuously from pluripotent stem cells which mature and become functionally specialized upon commitment… Expand
Highly Cited
1995
Highly Cited
1995
The main physiological regulator of erythropoiesis is the hematopoietic growth factor erythropoietin (EPO), which is induced in… Expand
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Highly Cited
1995
Highly Cited
1995
The binding of erythropoietin (EPO) to its receptor (EPO-R) activates the protein tyrosine kinase JAK2. The mechanism of JAK2… Expand
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Review
1993
Review
1993
RYTHROPOIETIN (EPO) is the principal growth factor E that promotes the viability, proliferation, and differentiation of mammalian… Expand
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Highly Cited
1992
Highly Cited
1992
The erythropoietin receptor (EPO-R) is a member of the recently described cytokine receptor superfamily. A constitutively active… Expand
Highly Cited
1990
Highly Cited
1990
The Friend spleen focus-forming virus envelope glycoprotein, gp55, binds to the murine erythropoietin receptor (EPO-R) and… Expand