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Erythropoietin Signaling Pathway

Known as: EPO Signaling Pathway 
Erythropoietin functions to increase the number of red blood cells. Thus, it has found utility as a drug for those needing to replenish erythrocytes… 
National Institutes of Health

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CRKL proteinCSNK2A1 wt AlleleELK1 wt AlleleEPO protein, human

Papers overview

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Highly Cited
2014
Highly Cited
2014
Amelioration of lipopolysaccharide-induced acute kidney injury by erythropoietin: involvement of mitochondria-regulated apoptosis.
Review
2011
Review
2011
Erythropoietin: A Hormone with Multiple Functions
Erythropoietin (EPO), the main hemopoietic hormone synthesized by the kidney as well as by the liver in fetal life, is implicated… 
Highly Cited
2002
Highly Cited
2002
Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury
Erythropoietin (EPO) plays an important role in the brain's response to neuronal injury. Systemic administration of recombinant… 
Highly Cited
2001
Highly Cited
2001
Erythropoietin Receptor-mediated Inhibition of Exocytotic Glutamate Release Confers Neuroprotection during Chemical Ischemia*
Erythropoietin (EPO) reduced Ca2+-induced glutamate (Glu) release from cultured cerebellar granule neurons. Inhibition was also… 
Highly Cited
2000
Highly Cited
2000
Erythropoietin stimulates proliferation of human renal carcinoma cells.
BACKGROUND We reported recently that normal human, rat, and mouse tubular cells express authentic erythropoietin-receptors (EPO-R… 
Highly Cited
1995
Highly Cited
1995
Localization of specific erythropoietin binding sites in defined areas of the mouse brain.
The main physiological regulator of erythropoiesis is the hematopoietic growth factor erythropoietin (EPO), which is induced in… 
Highly Cited
1995
Highly Cited
1995
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
Review
1993
Review
1993
Structure, function, and activation of the erythropoietin receptor.
RYTHROPOIETIN (EPO) is the principal growth factor E that promotes the viability, proliferation, and differentiation of mammalian… 
Highly Cited
1992
Highly Cited
1992
Homodimerization and constitutive activation of the erythropoietin receptor.
The erythropoietin receptor (EPO-R) is a member of the recently described cytokine receptor superfamily. A constitutively active… 
Highly Cited
1990
Highly Cited
1990
Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.
The Friend spleen focus-forming virus envelope glycoprotein, gp55, binds to the murine erythropoietin receptor (EPO-R) and… 
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