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Erythropoietin Signaling Pathway

Known as: EPO Signaling Pathway 
Erythropoietin functions to increase the number of red blood cells. Thus, it has found utility as a drug for those needing to replenish erythrocytes… Expand
National Institutes of Health

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48 relations
CRKL proteinCSNK2A1 wt AlleleELK1 wt AlleleEPO protein, human
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Papers overview

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Highly Cited
2002
Highly Cited
2002
Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury.
Erythropoietin (EPO) plays an important role in the brain's response to neuronal injury. Systemic administration of recombinant… Expand
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Highly Cited
2001
Highly Cited
2001
Erythropoietin receptor-mediated inhibition of exocytotic glutamate release confers neuroprotection during chemical ischemia.
Erythropoietin (EPO) reduced Ca(2+)-induced glutamate (Glu) release from cultured cerebellar granule neurons. Inhibition was also… Expand
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Highly Cited
2000
Highly Cited
2000
Erythropoietin stimulates proliferation of human renal carcinoma cells.
BACKGROUND We reported recently that normal human, rat, and mouse tubular cells express authentic erythropoietin-receptors (EPO-R… Expand
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Highly Cited
1997
Highly Cited
1997
Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors.
Homodimerization of the erythropoietin (EPO) receptor (EPO-R) in response to EPO binding transiently activates the receptor… Expand
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1997
1997
Distinct signaling from stem cell factor and erythropoietin in HCD57 cells.
A recent report (Wu, H., Klingmuller, U., Besmer, P., and Lodish, H. F. (1995) Nature 377, 242-246) documents the interaction of… Expand
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Highly Cited
1995
Highly Cited
1995
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals
The binding of erythropoietin (EPO) to its receptor (EPO-R) activates the protein tyrosine kinase JAK2. The mechanism of JAK2… Expand
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Highly Cited
1995
Highly Cited
1995
Localization of specific erythropoietin binding sites in defined areas of the mouse brain.
The main physiological regulator of erythropoiesis is the hematopoietic growth factor erythropoietin (EPO), which is induced in… Expand
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Review
1993
Review
1993
Structure, function, and activation of the erythropoietin receptor.
RYTHROPOIETIN (EPO) is the principal growth factor E that promotes the viability, proliferation, and differentiation of mammalian… Expand
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Highly Cited
1992
Highly Cited
1992
Homodimerization and constitutive activation of the erythropoietin receptor.
The erythropoietin receptor (EPO-R) is a member of the recently described cytokine receptor superfamily. A constitutively active… Expand
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Highly Cited
1990
Highly Cited
1990
Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism.
The Friend spleen focus-forming virus envelope glycoprotein, gp55, binds to the murine erythropoietin receptor (EPO-R) and… Expand
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