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Normal and Oncogenic Forms of the Receptor Tyrosine Kinase Kit
Kit is a receptor tyrosine kinase (RTK) that binds stem cell factor. This receptor ligand combination is important for normal hematopoiesis, as well as pigmentation, gut function, and reproduction.… Expand
Early signaling pathways activated by c-Kit in hematopoietic cells.
- D. Linnekin
- Biology, Medicine
- The international journal of biochemistry & cell…
- 1 October 1999
c-Kit is a receptor tyrosine kinase that binds stem cell factor (SCF). Structurally, c-Kit contains five immunoglobulin-like domains extracellularly and a catalytic domain divided into two regions by… Expand
Lyn Associates with the Juxtamembrane Region of c-Kit and Is Activated by Stem Cell Factor in Hematopoietic Cell Lines and Normal Progenitor Cells*
Stem cell factor (SCF) is a cytokine critical for normal hematopoiesis. The receptor for SCF is c-Kit, a receptor tyrosine kinase. Our laboratory is interested in delineating critical components of… Expand
Crosstalk Between BCR/ABL Oncoprotein and CXCR4 Signaling through a Src Family Kinase in Human Leukemia Cells
- A. Ptasznik, E. Urbanowska, +7 authors A. Gewirtz
- Chemistry, Medicine
- The Journal of experimental medicine
- 2 September 2002
Stromal-derived factor (SDF)-1 and its G protein–coupled receptor, CXCR4, regulate stem/progenitor cell migration and retention in the marrow and are required for hematopoiesis. We show here an… Expand
Lyn contributes to regulation of multiple Kit-dependent signaling pathways in murine bone marrow mast cells.
SCF induces autophosphorylation of Kit and activates a variety of signaling components including Jnks, Erks, PI 3 Kinase, the JAK-Stat pathway and members of the Src family. Previously we showed that… Expand
Stat1 associates with c-kit and is activated in response to stem cell factor.
Interaction of stem cell factor (SCF), a haematopoietic growth factor, with the receptor tyrosine kinase c-kit leads to autophosphorylation of c-kit as well as tyrosine phosphorylation of various… Expand
Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.
Stem cell factor (SCF) binds to c-Kit and is an important mediator of survival, growth, and function of hematopoietic progenitor cells and mast cells. Lyn and other Src family members are activated… Expand
Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant.
Stem cell factor (SCF) binds the receptor tyrosine kinase c-Kit and is critical for normal hematopoiesis. Substitution of valine for aspartic acid 816 (D816V) constitutively actives human c-Kit, and… Expand
JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor.
Stem cell factor (SCF) is a hematopoietic growth factor that interacts with the receptor tyrosine kinase, c-kit. We have found that SCF-stimulates rapid and transient tyrosine phosphorylation of JAK2… Expand
Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2.
Thrombopoietin (TPO) is a recently characterized growth and differentiation factor for megakaryocytes and platelets that exerts its effects via the receptor, c-MpI. This receptor is a member of the… Expand