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CRKL gene

Known as: V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like Gene, ONCOGENE CRKL, V-CRK AVIAN SARCOMA VIRUS CT10 ONCOGENE HOMOLOG-LIKE 
This gene plays a role in cell communication and signal transduction.
National Institutes of Health

Related topics

Related topics

2 relations
CRKL proteinSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Identification of somatic copy number variations in plasma cell free DNA correlating with intrinsic resistances to EGFR targeted therapy in T790M negative non-small cell lung cancer
Background About 20–30% EGFR-mutant non-small lung cancer show intrinsic resistance to EGFR targeted therapies. Compared to T790M… 
2018
2018
Quantitative proteomics reveals that miR‐222 inhibits erythroid differentiation by targeting BLVRA and CRKL
miR‐222 plays an important role in erythroid differentiation, but the potential targets of miR‐222 in the regulation of erythroid… 
2017
2017
[Phenotypic and genotypic analysis of a fetus carrying an intermediate 22q11.2 deletion encompassing the CRKL gene].
OBJECTIVE To delineate the phenotypic characteristics of 22q11.2 deletion syndrome and the role of CRKL gene in the pathogenesis… 
Review
2016
Review
2016
Delineation of a recognizable phenotype for the recurrent LCR22‐C to D/E atypical 22q11.2 deletion
The 22q11.2 deletion syndrome is typically caused by haploinsufficiency of a 3 Mb region that extends from LCR22‐A until LCR22‐D… 
2014
2014
CrkL regulates SDF-1-induced breast cancer biology through balancing Erk1/2 and PI3K/Akt pathways
Abstract The adapter protein CrkL is required for regulating the malignant potential of human cancers. However, the regulatory… 
2014
2014
CRKL amplification is rare as a mechanism for acquired resistance to kinase inhibitors in lung cancers with epidermal growth factor receptor mutation.
2014
2014
A Mouse Splice-Site Mutant and Individuals with Atypical Chromosome 22q11.2 Deletions Demonstrate the Crucial Role for Crkl in Craniofacial and Pharyngeal Development
The 22q11.2 deletion syndrome (22q11DS) is thought to be a contiguous gene syndrome caused by haploinsufficiency for a variable… 
2012
2012
An atypical 0.8 Mb inherited duplication of 22q11.2 associated with psychomotor impairment.
2010
2010
Recurrent amplification in the 22q11 region in laryngeal squamous cell carcinoma results in overexpression of the CRKL but not the MAPK1 oncogene.
Thirteen laryngeal squamous cell carcinoma cell lines were recently studied by array comparative genomic hybridization (array-CGH… 
2008
2008
Comparative proteomic analysis of differentially expressed proteins between K562 and K562/ADM cells.
BACKGROUND Multidrug resistance to chemotherapeutic agents is an important clinical problem during the treatment of leukemia. The… 
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