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CDK4 protein, human

Known as: Cyclin-Dependent Kinase 4, CMM3 protein, human, PSK-J3 protein, human 
Cyclin-dependent kinase 4 (303 aa, ~34 kDa) is encoded by the human CDK4 gene. This protein may be involved in cell cycle regulation.
National Institutes of Health

Related topics

Related topics

22 relations
CDC2 Protein KinaseCDK4 geneCDK4 wt AlleleCDK9 protein, human

Broader (1)

Cyclin-Dependent Kinase 4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
The role of CDK6 in cancer
The regulation and function of cyclin‐dependent kinase 6 (CDK6)‐ and cyclin‐dependent kinase 4 (CDK4)‐cyclin complexes are… 
2018
2018
Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta)
Conservation of the genetic resources of endangered animals is crucial for future generations. The loggerhead sea turtle (Caretta… 
2015
2015
Immortalization of Fetal Bovine Colon Epithelial Cells by Expression of Human Cyclin D1, Mutant Cyclin Dependent Kinase 4, and Telomerase Reverse Transcriptase: An In Vitro Model for Bacterial…
Cattle are the economically important animals in human society. They are essential for the production of livestock products such… 
2015
2015
Unexpected role of CDK4 in a G2/M checkpoint
Cellular senescence is a state of permanent cell cycle arrest in response to a diverse range of stressors. In physiological… 
Highly Cited
2011
Highly Cited
2011
Transforming growth factor‐β adaptor, β2‐spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer
Transforming growth factor beta (TGF‐β) is an important regulator of cell growth, and loss of TGF‐β signaling is a hallmark of… 
2008
2008
Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases
Cyclin dependent kinase 4 is a key regulator of the cell cycle and its activity is frequently deregulated in cancer. The activity… 
2007
2007
3D-QSAR and molecular docking study on bisarylmaleimide series as glycogen synthase kinase 3, cyclin dependent kinase 2 and cyclin dependent kinase 4 inhibitors: an insight into the criteria for…
2006
2006
3D-QSAR CoMFA study on indenopyrazole derivatives as cyclin dependent kinase 4 (CDK4) and cyclin dependent kinase 2 (CDK2) inhibitors.
2001
2001
Identification of selective inhibitors of cyclin dependent kinase 4.
1998
1998
Differential effects of estradiol and its analogs on cyclin D1 and CDK4 expression in estrogen receptor positive MCF-7 and estrogen receptor-transfected MCF-10AEwt5 cells.
Estradiol stimulates the growth of a majority of human breast tumors containing the estrogen receptors (ERs), proteins that… 
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