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CDC2 Protein Kinase

Known as: p34 (cdc2), p34CDC2, p34(CDC2) 
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the… 
National Institutes of Health

Related topics

Related topics

40 relations
CDC25 and CHK1 Regulatory PathwayCDK1 geneCDK4 protein, humanCell Cycle

Narrower (3)

CDC2A protein, ArabidopsisCys-cdc2 (8-20)PSTAIR peptide

Broader (1)

Cell Cycle Proteins

Papers overview

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Highly Cited
1998
Highly Cited
1998
MPF amplification in Xenopus oocyte extracts depends on a two-step activation of cdc25 phosphatase.
The activation of Cdc2 kinase induces the entry into M-phase of all eukaryotic cells. We have developed a cell-free system… 
Highly Cited
1998
Highly Cited
1998
Negative regulation of Cdc18 DNA replication protein by Cdc2.
Fission yeast Cdc18, a homologue of Cdc6 in budding yeast and metazoans, is periodically expressed during the S phase and… 
Highly Cited
1998
Highly Cited
1998
Activation of the p42 mitogen-activated protein kinase pathway inhibits Cdc2 activation and entry into M-phase in cycling Xenopus egg extracts.
We have added constitutively active MAP kinase/ERK kinase (MEK), an activator of the mitogen-activated protein kinase (MAPK… 
Highly Cited
1994
Highly Cited
1994
Regulation of M-phase promoting factor activity during development of mouse male germ cells.
While the role of M-phase promoting factor (MPF) in controlling meiosis in oocytes has been well documented, very little is known… 
Highly Cited
1993
Highly Cited
1993
Two Fission Yeast B-Type Cyclins, Cig2 and Cdc13, Have Different Functions in Mitosis
Cyclin B interacts with Cdc2 kinase to induce cell cycle events, particularly those of mitosis. The existence of cyclin B… 
Highly Cited
1991
Highly Cited
1991
Tyrosine phosphorylation of p34cdc2 and p42 during meiotic maturation of Xenopus oocyte. Antagonistic action of okadaic acid and 6-DMAP.
The tyrosine phosphorylation/dephosphorylation of p34cdc2 was estimated by immunoblotting with antiphosphotyrosine antibody… 
Highly Cited
1991
Highly Cited
1991
Mutations at sites involved in Suc1 binding inactivate Cdc2
suc1+ encodes an essential cell cycle regulator of the fission yeast Schizosaccharomyces pombe. Its product, a 13-kDa protein… 
1991
1991
Structural basis of specific and efficient phosphorylation of peptides derived from p34cdc2 by a pp60src-related protein tyrosine kinase.
1991
1991
Phosphorylation of caldesmon by cdc2 kinase.
A recent report that mitosis-specific phosphorylation causes the nonmuscle caldesmon to dissociate from microfilaments (Yamashiro… 
Highly Cited
1990
Highly Cited
1990
A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts
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