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CDC2 Protein Kinase

Known as: p34 (cdc2), p34CDC2, p34(CDC2) 
Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Protein phosphorylation during the cell cycle may be an all-or-none process in many instances. All-or-None Phosphorylation… Expand
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Review
2009
Review
2009
Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated… Expand
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Highly Cited
2000
Highly Cited
2000
Protein kinases have proved to be largely resistant to the design of highly specific inhibitors, even with the aid of… Expand
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Highly Cited
1999
Highly Cited
1999
Recently Gadd45, a p53-regulated stress protein, has been implicated in the activation of a G2/M checkpoint after damage by UV… Expand
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Highly Cited
1997
Highly Cited
1997
The G2 DNA damage checkpoint ensures maintenance of cell viability by delaying progression into mitosis in cells which have… Expand
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Highly Cited
1997
Highly Cited
1997
Entry into mitosis requires the activity of the Cdc2 kinase. Cdc2 associates with the B-type cyclins, and the Cdc2-cyclin B… Expand
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Highly Cited
1995
Highly Cited
1995
Cdc2 is the cyclin-dependent kinase that controls entry of cells into mitosis. Phospho-rylation of Cdc2 on threonine-14 and… Expand
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Highly Cited
1994
Highly Cited
1994
Phosphorylation by the CDK-activating kinase (CAK) is a required step in the activation of cyclin-dependent kinases. We have… Expand
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Highly Cited
1991
Highly Cited
1991
A new human cyclin, named cyclin E, was isolated by complementation of a triple cln deletion in S. cerevisiae. Cyclin E showed… Expand
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Highly Cited
1989
Highly Cited
1989
The cdc2+ protein kinase (pp34) is found to be phosphorylated on tyrosine as well as serine and threonine residues in… Expand
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