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New functional activities for the p21 family of CDK inhibitors.
The association of cdk4 with D-type cyclins to form functional kinase complexes is comparatively inefficient. This has led to the suggestion that assembly might be a regulated step. In this report we… Expand
Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.
Cyclin E/Cdk2 acts at the G1/S-phase transition to promote the E2F transcriptional program and the initiation of DNA synthesis. To explore further how cyclin E/Cdk2 controls S-phase events, we… Expand
The ZO-1–associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density
Epithelial tight junctions regulate paracellular permeability, restrict apical/basolateral intramembrane diffusion of lipids, and have been proposed to participate in the control of epithelial cell… Expand
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?
In the past decade, CHK2 has emerged as an important multifunctional player in the DNA-damage response signalling pathway. Parallel studies of the human CHEK2 gene have also highlighted its role as a… Expand
Microinjection of recombinant p21rho induces rapid changes in cell morphology
- H. Paterson, A. Self, M. Garrett, I. Just, K. Aktories, A. Hall
- Biology, Medicine
- The Journal of cell biology
- 1 September 1990
The rho proteins, p21rho, are ubiquitously expressed guanine nucleotide binding proteins with approximately 30% amino acid homology to p21ras, but their biochemical function is unknown. We show here… Expand
GDI1 encodes a GDP dissociation inhibitor that plays an essential role in the yeast secretory pathway.
GTP binding proteins of the Sec4/Ypt/rab family regulate distinct vesicular traffic events in eukaryotic cells. We have cloned GDI1, an essential homolog of bovine rab GDI (GDP dissociation… Expand
In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202
- F. Raynaud, S. Whittaker, +12 authors P. Workman
- Medicine, Biology
- Clinical Cancer Research
- 1 July 2005
Purpose: To investigate pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine, and CYC202 (R-roscovitine;… Expand
Trans‐activation of the DNA‐damage signalling protein kinase Chk2 by T‐loop exchange
The protein kinase Chk2 (checkpoint kinase 2) is a major effector of the replication checkpoint. Chk2 activation is initiated by phosphorylation of Thr68, in the serine–glutamine/threonine–glutamine… Expand
Bcr encodes a GTPase-activating protein for p21rac
MORE than thirty small guanine nucleotide-binding proteins related to the ras-encoded oncoprotein, termed Ras or p21ras, are known1. They regulate many fundamental processes in all eukaryotic cells,… Expand
The Cyclin-dependent Kinase Inhibitor CYC202 (R-Roscovitine) Inhibits Retinoblastoma Protein Phosphorylation, Causes Loss of Cyclin D1, and Activates the Mitogen-activated Protein Kinase Pathway
Deregulation of the cell cycle commonly occurs during tumorigenesis, resulting in unrestricted cell proliferation and independence from mitogens. Cyclin-dependent kinase inhibitors have the potential… Expand