• Publications
  • Influence
mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF†
ABSTRACT Mammalian target of rapamycin (mTOR) is a key regulator of cell growth acting via two independent targets, ribosomal protein S6 kinase 1 (S6K1) and 4EBP1. While each is known to regulateExpand
  • 386
  • 26
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Increased transcription of ribosomal RNA genes (rDNA) by RNA Polymerase I is a common feature of human cancer, but whether it is required for the malignant phenotype remains unclear. We show thatExpand
  • 353
  • 23
  • PDF
The renin–angiotensin system and cancer: old dog, new tricks
For cancers to develop, sustain and spread, the appropriation of key homeostatic physiological systems that influence cell growth, migration and death, as well as inflammation and the expansion ofExpand
  • 300
  • 22
ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells.
ATRX (alpha thalassemia/mental retardation syndrome X-linked) belongs to the SWI2/SNF2 family of chromatin remodeling proteins. Besides the ATPase/helicase domain at its C terminus, it contains aExpand
  • 307
  • 21
Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.
Deregulated ribosomal RNA synthesis is associated with uncontrolled cancer cell proliferation. RNA polymerase (Pol) I, the multiprotein complex that synthesizes rRNA, is activated widely in cancer.Expand
  • 344
  • 18
  • PDF
Direct Actions of Urotensin II on the Heart: Implications for Cardiac Fibrosis and Hypertrophy
Abstract— Urotensin II (UII) is a somatostatin-like peptide recently identified as a potent vasoconstrictor. In this study, we examined whether UII promotes cardiac remodeling through nonhemodynamicExpand
  • 194
  • 17
UBF levels determine the number of active ribosomal RNA genes in mammals
In mammals, the mechanisms regulating the number of active copies of the ∼200 ribosomal RNA (rRNA) genes transcribed by RNA polymerase I are unclear. We demonstrate that depletion of theExpand
  • 162
  • 15
  • PDF
Adenoviral-Directed Expression of the Type 1A Angiotensin Receptor Promotes Cardiomyocyte Hypertrophy via Transactivation of the Epidermal Growth Factor Receptor
Angiotensin II (Ang II) may cause cardiac hypertrophy via type 1 Ang II receptors (AT1) on cardiomyocytes and through growth factors released from cardiac fibroblasts. Whereas cardiomyocyte-specificExpand
  • 179
  • 9
MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation
The regulation of cell mass (cell growth) is often tightly coupled to the cell division cycle (cell proliferation). Ribosome biogenesis and the control of rDNA transcription through RNA polymerase IExpand
  • 176
  • 9
  • PDF
Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1
We have previously demonstrated that the protein encoded by the retinoblastoma susceptibility gene (Rb) functions as a regulator of transcription by RNA polymerase I (rDNA transcription) byExpand
  • 141
  • 8