Cyclin-Dependent Kinase 4

Known as: Cyclin D-Dependent Kinase CDK4, PSK J3 Kinase, p34PSK-J3 Kinase 
Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN D to phosphorylate RETINOBLASTOMA PROTEIN. CDK4… (More)
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer and is a biomarker of cancer… (More)
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Highly Cited
2006
Highly Cited
2006
The p16INK4a tumour suppressor accumulates in many tissues as a function of advancing age. p16INK4a is an effector of senescence… (More)
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Review
2005
Review
2005
Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that… (More)
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Highly Cited
2004
Highly Cited
2004
Cdk4 and Cdk6 are thought to be essential for initiation of the cell cycle in response to mitogenic stimuli. Previous studies… (More)
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Highly Cited
1999
Highly Cited
1999
The widely prevailing view that the cyclin-dependent kinase inhibitors (CKIs) are solely negative regulators of cyclin-dependent… (More)
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Highly Cited
1996
Highly Cited
1996
Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease… (More)
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Highly Cited
1995
Highly Cited
1995
p21Cip1 is a cyclin-dependent kinase (Cdk) inhibitor that is transcriptionally activated by p53 in response to DNA damage. We… (More)
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Highly Cited
1994
Highly Cited
1994
Using a yeast interaction screen to search for proteins that interact with cyclin D1-Cdk4, we identified a 27 kDa mouse protein… (More)
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Highly Cited
1993
Highly Cited
1993
THE division cycle of eukaryotic cells is regulated by a family of protein kinases known as the cyclin-dependent kinases (CDKs)1… (More)
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Highly Cited
1993
Highly Cited
1993
The product (pRb) of the retinoblastoma gene (RB-1) prevents S-phase entry during the cell cycle, and inactivation of this growth… (More)
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