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CDK4 gene

Known as: CDK4, Cyclin-Dependent Kinase 4 Gene, CELL DIVISION KINASE 4 
This gene is involved in G1 stage cell cycle progression.
National Institutes of Health

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CDK4 protein, humanCell Cycle ControlCell ProliferationCyclin-Dependent Kinase 4

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CDK4 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
MicroRNA-338-3p Inhibits Proliferation and Promotes Apoptosis of Multiple Myeloma Cells Through Targeting Cyclin-Dependent Kinase 4.
MicroRNA-338-3p (miR-338-3p) has been reported to be a tumor suppressor in multiple cancer types. However, the biological role of… 
2017
2017
A3 adenosine receptor agonist induce G1 cell cycle arrest via Cyclin D and cyclin-dependent kinase 4 pathways in OVCAR-3 and Caov-4 cell lines
Aim of the Study: The cell cycle, a vital process that involves in cells' growth and division, lies at the heart of cancer. It… 
2017
2017
Arctigenin, a natural lignan compound, induces G0/G1 cell cycle arrest and apoptosis in human glioma cells.
The aim of the current study was to investigate the anticancer potential of arctigenin, a natural lignan compound, in malignant… 
2017
2017
Pien Tze Huang inhibits the growth of hepatocellular carcinoma cells by upregulating miR-16 expression.
Hepatocellular carcinoma (HCC) is characterized by uncontrolled proliferation and the deregulation of apoptotic signaling… 
2005
2005
A Mimic of p21WAF1/CIP1 Ameliorates Murine Lupus1
Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by the production of high levels of affinity… 
2004
2004
Profiling the molecular difference between Patched- and p53-dependent rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a highly malignant tumor that is histologically related to skeletal muscle, yet genetic and molecular… 
1999
1999
Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture.
1997
1997
Infrequent mutations of p16INK4A and p15INK4B genes in human pituitary adenomas.
The p16INK4A and p15INK4B genes on chromosome 9p21 encode the p16 and p15 inhibitors of cyclin D/cyclin-dependent kinase 4… 
1995
1995
Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma.
B-cell non-Hodgkin's lymphoma (NHL) is a heterogeneous lymphoid malignancy consisting of several histologic types. Alterations in… 
1995
1995
Low frequency of CDKN2 mutation in endometrial carcinomas
The CDKN2 gene on chromosome 9p21 encodes the p16 inhibitor of cyclin D/cyclin‐dependent kinase 4 complexes. Mutations and… 
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