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- Publications
- Influence
Daclatasvir Plus Asunaprevir for Chronic HCV Genotype 1b Infection
All‐oral combinations of direct‐acting antivirals may improve efficacy and safety outcomes for patients with hepatitis C virus (HCV) infection, particularly those who are poor candidates for current… Expand
Characterization of a Stellate Cell Activation-associated Protein (STAP) with Peroxidase Activity Found in Rat Hepatic Stellate Cells*
- N. Kawada, D. B. Kristensen, +4 authors K. Yoshizato
- Biology, Medicine
- The Journal of Biological Chemistry
- 6 July 2001
A proteome approach for the molecular analysis of the activation of rat stellate cell, a liver-specific pericyte, led to the discovery of a novel protein named STAP (stellate… Expand
Effect of antioxidants, resveratrol, quercetin, and N‐acetylcysteine, on the functions of cultured rat hepatic stellate cells and kupffer cells
Effects of antioxidants, resveratrol, quercetin, and N‐acetylcysteine (NAC) on the functions of cultured rat hepatic stellate cells and Kupffer cells were studied. These compounds dose‐dependently… Expand
Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats
- K. Kinoshita, Y. Iimuro, +7 authors K. Ikeda
- Biology, Medicine
- Gut
- 24 November 2006
Background: Liver cirrhosis, which is caused by the accumulation of extracellular matrix materials, is a serious clinical problem that can progress to hepatic failure. Transforming growth factor-β… Expand
MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis
- T. Ogawa, M. Enomoto, +4 authors N. Kawada
- Biology, Medicine
- Gut
- 20 January 2012
Background MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. Objective To explore miRNAs that are regulated with the progression of liver fibrosis… Expand
Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population
- Y. Sumida, Masato Yoneda, +15 authors T. Okanoue
- Medicine
- BMC Gastroenterology
- 5 January 2012
BackgroundA reliable and inexpensive noninvasive marker of hepatic fibrosis is required in patients with nonalcoholic fatty liver disease (NAFLD). FIB4 index (based on age, aspartate aminotransferase… Expand
Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis
- Kazuki Nakatani, H. Okuyama, +6 authors K. Yoshizato
- Biology, Medicine
- Laboratory Investigation
- 2004
Cytoglobin/stellate cell activation-associated protein (Cygb/STAP) consists of a new class of hexacoordinate globin superfamily, which was recently discovered by a proteome analysis on the rat… Expand
Inflammation and fibrogenesis in steatohepatitis
Nonalcoholic fatty liver disease consists of a range of disorders characterized by excess accumulation of triglyceride within the liver. Whereas simple steatosis is clinically benign, nonalcoholic… Expand
Structural basis of human cytoglobin for ligand binding.
- H. Sugimoto, Masatomo Makino, H. Sawai, N. Kawada, K. Yoshizato, Y. Shiro
- Chemistry, Medicine
- Journal of molecular biology
- 11 June 2004
Cytoglobin (Cgb), a newly discovered member of the vertebrate globin family, binds O(2) reversibly via its heme, as is the case for other mammalian globins (hemoglobin (Hb), myoglobin (Mb) and… Expand