Solid-state characterization of rifampicin samples and its biopharmaceutic relevance.
- S. Agrawal, Y. Ashokraj, P. Bharatam, O. Pillai, R. Panchagnula
- Materials ScienceEuropean Journal of Pharmaceutical Sciences
- 1 June 2004
N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα and induce apoptosis in G1/S phase.
- Ashish T. Baviskar, Chetna Madaan, P. Bharatam
- Chemistry, BiologyJournal of Medicinal Chemistry
- 23 June 2011
N-Fused aminoimidazoles showed potent anticancer activities in kidney and breast cancer cell lines, low toxicity to normal cells, relatively higher potency compared to etoposide and 5-fluorouracil in kidney cancer cell Lines, and potent inhibition in cell migration.
Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1
- Anmada Nayak, S. Satapathy, C. Kundu
- Biology, ChemistryScientific Reports
- 5 February 2016
NQC induced apoptosis in cancers through inhibition of HH-GLI cascade by GLI1, and detail interaction of QC-DNA- GLI complex can pave path for anticancer drug design.
Characterization of forced degradation products and in silico toxicity prediction of Sofosbuvir: A novel HCV NS5B polymerase inhibitor.
- D. Swain, G. Samanthula, S. Bhagat, P. Bharatam, V. Akula, B. N. Sinha
- ChemistryJournal of Pharmaceutical and Biomedical Analysis
- 20 February 2016
Molecular dynamics simulation studies of GSK-3β ATP competitive inhibitors: understanding the factors contributing to selectivity
- M. Arfeen, Rahul Patel, Tosif Khan, P. Bharatam
- Chemistry, BiologyJournal of Biomolecular Structure and Dynamics
- 27 November 2015
The results obtained in this study can be utilized to design new selective GSK-3 ATP competitive inhibitors and suggested the additional role of Gln185 in determining the selectivity of maleimides.
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies
- Kamaljit Singh, H. Kaur, K. Chibale, J. Balzarini, S. Little, P. Bharatam
- Chemistry, BiologyEuropean Journal of Medicinal Chemistry
- 13 March 2012
Biguanides: Species with versatile therapeutic applications.
- Deepika Kathuria, Akshay D Raul, Pravin J. Wanjari, P. Bharatam
- Biology, ChemistryEuropean journal of medicinal chemistry
- 24 March 2021
Sulfonamide vs. sulfonimide: tautomerism and electronic structure analysis of N-heterocyclic arenesulfonamides
- Sumit S. Chourasiya, D. Patel, C. Nagaraja, A. Chakraborti, P. Bharatam
- Chemistry
- 7 August 2017
A systematic study of the structure and electronic properties of N-heterocyclic arenesulfonamides (NHAS) was performed using experimental and theoretical methods. Ten new examples of NHAS with…
Origins of the specificity of inhibitor P218 toward wild-type and mutant PfDHFR: a molecular dynamics analysis
- Sheenu Abbat, V. Jain, P. Bharatam
- Chemistry, BiologyJournal of Biomolecular Structure and Dynamics
- 16 July 2015
It was found that mutant residues do not reduce the binding affinity of P218 to PfDHFR, in contrast, Cys59Arg mutation strongly favors inhibitor binding to quadruple-mutant Pf DHFR.
Modeling and informatics in designing anti-diabetic agents.
- P. Bharatam, D. Patel, L. Adane, A. Mittal, S. Sundriyal
- Biology, ChemistryCurrent pharmaceutical design
- 30 November 2007
A review of the rational approaches reported in designing anti-diabetic agents is presented in this article and can be emulated in many other therapeutic areas.
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