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Bromodomain

A motif common in chromatin remodeling factors. It consists of approximately 110 amino acids in a left-handed up-and-down four helix bundle with a… 
National Institutes of Health

Related topics

Related topics

10 relations
BRD4 protein, humanBRDT protein, humanBromodomain Containing Protein 2Bromodomain-Containing Protein 3

Papers overview

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2016
2016
MiR-137 silencing of BRD 4 suppresses oral squamous cell carcinoma cells proliferation , migration and invasion
Objective: In order to study the role of miR-137 in oral squamous cell carcinoma (OSCC). Materials and methods: The gene… 
2015
2015
Targeting BRG 1 Chromatin Remodeler via Its Bromodomain for Enhanced Tumor Cell Radiosensitivity In Vitro and In Vivo
Radiotherapy treats cancer by inducing DNA double-strand breaks (DSB) in tumor cells using ionizing radiation. However, DNA… 
Review
2014
Review
2014
MYELOID NEOPLASIA shRNA screening identi fi es JMJD 1 C as being required for leukemia maintenance
Translocations involvingmixed lineage leukemia (MLL) gene occur frequently in acute leukemia, especially in childhood and… 
Review
2011
Review
2011
MLL (myeloid/lymphoid or mixed lineage leukemia)
Review on MLL (myeloid/lymphoid or mixed lineage leukemia), with data on DNA, on the protein encoded, and where the gene is… 
Review
2011
Review
2011
EP300 (E1A binding protein p300)
Review on EP300 (E1A binding protein p300), with data on DNA, on the protein encoded, and where the gene is implicated. 
2011
2011
Histone H 3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms
There is a close relationship between histone acetylation and ATP-dependent chromatin remodeling that is not fully understood. We… 
2010
2010
Tetrahydroquinoline derivatives as bromodomain inhibitors
Tetrahydroquinoline compounds of formula (I) Or a salt thereof, a pharmaceutical composition comprising such a compound, and… 
2010
2010
Benzodiazepine bromodomain inhibitor
The formula (I) from the benzodiazepine compounds and salts thereof, pharmaceutical compositions containing such compounds, and… 
2009
2009
PROTEIN STRUCTURE AND FOLDING : Structural basis for acetylated histone H 4 recognition by the human BRD 2 bromodomain
These authors contributed equally to this work. Present address: Laboratory of Viral Diseases, National Institute of Allergy and… 
2005
2005
Reconstitution of papillomavirus E 2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd 4 bromodomain protein
The papillomavirus E2 protein functions in viral transcriptional regulation, DNA replication, and episomal genome maintenance…