Bromodomain

A motif common in chromatin remodeling factors. It consists of approximately 110 amino acids in a left-handed up-and-down four helix bundle with a… (More)

Topic mentions per year

Topic mentions per year

2000-2018
05010020002018

Papers overview

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Highly Cited
2015
Highly Cited
2015
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in leukemia, yet its regulatory function in this… (More)
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Highly Cited
2013
Highly Cited
2013
Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date… (More)
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Highly Cited
2012
Highly Cited
2012
Male germ cell differentiation is a highly regulated multistep process initiated by the commitment of progenitor cells into… (More)
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2011
2011
Histone-lysine acetylation is a vital chromatin post-translational modification involved in the epigenetic regulation of gene… (More)
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Highly Cited
2008
Highly Cited
2008
Previous work identified the Rap1 GTPase-activating protein Sipa1 as a germ-line-encoded metastasis modifier. The bromodomain… (More)
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Highly Cited
2006
Highly Cited
2006
The papillomavirus E2 regulatory protein has essential roles in viral transcription and the initiation of viral DNA replication… (More)
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2005
2005
Cyclin A is regulated primarily through transcription control during the mammalian cell cycle. A dual mechanism of cyclin A… (More)
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Highly Cited
2003
Highly Cited
2003
The histone code hypothesis proposes that covalently modified histone tails are binding sites for specific proteins. In vitro… (More)
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Highly Cited
2000
Highly Cited
2000
The basal transcription factor TFIID consists of the TATA-binding protein (TBP) and TBP-associated factors (TAFs). Yeast Taf67 is… (More)
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2000
2000
The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription… (More)
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