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Bromodomain

A motif common in chromatin remodeling factors. It consists of approximately 110 amino acids in a left-handed up-and-down four helix bundle with a… 
National Institutes of Health

Related topics

Related topics

10 relations
BRD4 protein, humanBRDT protein, humanBromodomain Containing Protein 2Bromodomain-Containing Protein 3

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Epigenetics in Melanoma Development and Drug Resistance
Melanomas, which originate from melanocytic cells, mainly develop in the skin but can also arise at other body sites. The disease… 
Review
2017
Review
2017
A chemical probe for the ATAD 2 bromodomain
ATAD2 is a cancer-associated protein whose bromodomain has been described as among the least druggable of that target class… 
2015
2015
Targeting BRG 1 Chromatin Remodeler via Its Bromodomain for Enhanced Tumor Cell Radiosensitivity In Vitro and In Vivo
Radiotherapy treats cancer by inducing DNA double-strand breaks (DSB) in tumor cells using ionizing radiation. However, DNA… 
2014
2014
Small Molecule Therapeutics BET Protein Antagonist JQ 1 Is Synergistically Lethal with FLT 3 Tyrosine Kinase Inhibitor ( TKI ) and Overcomes Resistance to FLT 3-TKI in AML Cells Expressing FLT-ITD
Recently, treatment with bromodomain and extraterminal protein antagonist (BA) such as JQ1 has been shown to inhibit growth and… 
Review
2014
Review
2014
MYELOID NEOPLASIA shRNA screening identi fi es JMJD 1 C as being required for leukemia maintenance
Translocations involvingmixed lineage leukemia (MLL) gene occur frequently in acute leukemia, especially in childhood and… 
Review
2011
Review
2011
MLL (myeloid/lymphoid or mixed lineage leukemia)
Review on MLL (myeloid/lymphoid or mixed lineage leukemia), with data on DNA, on the protein encoded, and where the gene is… 
2011
2011
Histone H 3 tail acetylation modulates ATP-dependent remodeling through multiple mechanisms
There is a close relationship between histone acetylation and ATP-dependent chromatin remodeling that is not fully understood. We… 
2010
2010
Tetrahydroquinoline derivatives as bromodomain inhibitors
Tetrahydroquinoline compounds of formula (I) Or a salt thereof, a pharmaceutical composition comprising such a compound, and… 
2010
2010
Imidazo [4,5-c] quinoline derivatives as bromodomain inhibitors
The novel compounds of formula (I) And salts thereof, pharmaceutical compositions containing such compounds and their use in… 
2007
2007
Phylogeny and structure of theRING3 gene
In the search for novel genes in the human major histocompatibility complex ( MHC) class II region on chromosome 6p21.3, we and… 
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