Yoshihiro Nakamura

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INTRODUCTION Osteoarthritis (OA) is a whole joint disease, and characterized by progressive degradation of articular cartilage, synovial hyperplasia, bone remodeling and angiogenesis in various joint tissues. Exosomes are a type of microvesicles (MVs) that may play a role in tissue-tissue and cell-cell communication in homeostasis and diseases. We(More)
To optimize large-scale distribution networks, solving about 1000 middle scale (around 40 cities) TSPs (traveling salesman problems) within an interactive length of time (max. 30 seconds) is required. Yet, expert-level (less than 3% of errors) accuracy is necessary. To realize the above requirements, a multi-world intelligent GA method was developed. This(More)
The objective of the present study is to improve teacher efficiency so that large numbers of students can be educated , while at the same time implementing an individual approach to education in which each student's progress is taken into account. To achieve this objective, we propose an education system for groups of students at a similar stage of(More)
With the ongoing development and expansion of communication networks and sensors, massive amounts of data are continuously generated in real time from real environments. Beforehand, prediction of a distribution underlying such data is difficult; furthermore, the data include substantial amounts of noise. These factors make it difficult to estimate(More)
A tracheocutaneous fistula may develop when a tracheostomy orifice epithelializes during a prolonged course of healing or undernutrition. Various techniques for closing such fistulae have been reported. However, a standard procedure has not yet been established. We, herein, present a case involving a 35-year-old woman who developed a tracheocutaneous(More)
BACKGROUND Giant cell myocarditis (GCM) is rapidly progressive fulminant myocarditis causing death or requiring cardiac transplantation despite various immunosuppression therapies. CASE REPORT A 28-year-old woman with progressive shortness of breath and palpitation following an upper respiratory infection was referred to our institution. On admission,(More)
To help unskilled users operate their networks, I propose a method for composing network operation services based on the knowledge base provided in Web ontology languages. To achieve this, I propose a method for automatic integration of proprietary operation service interfaces and integrated component operation services at the semantic level. This method(More)
Large-scale distribution network simulation applicable to supply-chain management requires to solve hundreds of time-constraint large-scale (max 2000 cities) traveling salesman problems (TSP) within interactive response time, with practicable optimality. To meet this requirement, a selfish-gene tolerant type GA is proposed. Here, each gene of an individual(More)