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Bromodomain-Containing Protein 3

Known as: BRD3, RING3-Like Protein 
Bromodomain-containing protein 3 (726 aa, ~80 kDa) is encoded by the human BRD3 gene. This protein may play a role in the regulation of both histone… 
National Institutes of Health

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Related topics

3 relations
BRD3 geneBromodomainGenes, Regulator

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract P3-06-07: The BET bromodomain inhibitors ZEN-3694 and ZEN-3309 targets several mechanisms of resistance to endocrine therapies in preclinical models of ER+ breast cancers
More than 200,000 women are diagnosed with breast cancer every year in the United States. About 80% of these cases are estrogen… 
2018
2018
BET inhibitors: Betting on improved outcomes in uterine serous carcinoma
During the last decade, cancer research has significantly evolved into precision medicine and targeted therapies are now part of… 
2017
2017
SPOP tips the balance of BETs in cancer
Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its… 
Review
2016
Review
2016
Abstract 4693: Mechanism-based combination strategies for BET inhibitors in NUT midline carcinoma
NUT midline carcinoma (NMC) is a highly aggressive squamous cell cancer that responds poorly to standard chemotherapuetic… 
2015
2015
Function of bromodomain and extra-terminal motif proteins (BETs) in GATA1-mediated transcription
Bromodomain and Extra-Terminal motif proteins (BETs) associate with acetylated histones and transcription factors. While… 
2015
2015
Abstract 3525: The BET inhibitor INCB054329 is efficacious as a single agent or in combination with targeted agents in colorectal cancer models
The Bromodomain and extra-terminal (BET) family of proteins consists of BRD2, BRD3, BRD4 and BRDT. Each BET protein contains two… 
2014
2014
Prostate cancer: BETting on epigenetic therapy
The bromodomain and extraterminal (BET) family of chromatin readers are important for androgen receptor-mediated transcription… 
2014
2014
Preclinical Evaluation of the BET-Bromodomain (BET-BRD) Inhibitor OTX015 in Leukemia Cell Lines Harboring the JAK2 V617F Mutation
Background: Exposure of cancer cells to BET-BRD protein inhibitors has been associated with a significant downregulation of C-MYC… 
2011
2011
A Commentary on microRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma
A Commentary on microRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous… 
2008
2008
Thermodynamic analysis of acetylation-dependent Pb1 bromodomain-histone H3 interactions.
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