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BRD4 protein, human
Known as:
Protein HUNK1
, Bromodomain-Containing Protein 4
, bromodomain containing 4 protein, human
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Bromodomain-containing protein 4 (1362 aa, ~152 kDa) is encoded by the human BRD4 gene. This protein plays a role in the mitotic process.
National Institutes of Health
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Related topics
Related topics
12 relations
BRD4 gene
Bromodomain
Cell Cycle Control
Cell Nucleus
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Broader (2)
Nuclear Proteins
TRANSCRIPTION FACTOR
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
From Chromatin Readers to Heart Failure: BET Protein Family Members in Cardiac Remodeling
Dawid Lbik
2019
Corpus ID: 201987145
Heart failure (HF) is the pathologic inability of the heart to supply the body with sufficient amounts of oxygen-rich blood. This…
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2018
2018
ZMYND 8 acetylation mediates HIF-dependent breast cancer progression and metastasis
Yan Chen
,
Bo Zhang
,
+10 authors
W. Luo
2018
Corpus ID: 4850100
Altered epigenetic reprogramming contributes to breast cancer progression and metastasis. How the epigenetic reader mediates…
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2018
2018
Abstract P3-06-07: The BET bromodomain inhibitors ZEN-3694 and ZEN-3309 targets several mechanisms of resistance to endocrine therapies in preclinical models of ER+ breast cancers
O. Kharenko
,
Reena G. Patel
,
+6 authors
H. Hansen
2018
Corpus ID: 79936482
More than 200,000 women are diagnosed with breast cancer every year in the United States. About 80% of these cases are estrogen…
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Review
2016
Review
2016
Abstract 4695: Functional group elaboration of a low molecular weight fragment to yield the novel BET family bromodomain inhibitor ABBV-075
K. F. McDaniel
,
Le Wang
,
+26 authors
W. Kati
2016
Corpus ID: 78748280
Phenotypic cell-based screening assays combined with affinity chromatography and mass-spectrometry identified the BET family of…
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2015
2015
Function of bromodomain and extra-terminal motif proteins (BETs) in GATA1-mediated transcription
A. Stonestrom
2015
Corpus ID: 83813997
Bromodomain and Extra-Terminal motif proteins (BETs) associate with acetylated histones and transcription factors. While…
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2014
2014
Cancer Therapy : Preclinical BET Bromodomain Inhibition of MYC-Ampli fi ed Medulloblastoma
P. Bandopadhayay
,
G. Bergthold
,
+22 authors
Yoon-Jae Cho
2014
Corpus ID: 9192358
Purpose: MYC-amplified medulloblastomas are highly lethal tumors. Bromodomain and extraterminal (BET) bromodomain inhibition has…
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Review
2014
Review
2014
Molecular Cell Previews RePlace Your BETs : The Dynamics of Super Enhancers
Paulo P. Amaral
,
Andrew J. Bannister
2014
Corpus ID: 207767786
Complex organisms comprise a multitude of specialized cells that work together to specify tissue functions and maintain…
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2010
2010
Understanding the role of Brd4 in the maintenance of human embryonic stem cells.
M. Lim
2010
Corpus ID: 89159229
2009
2009
Multiple Functions of BRD4 in E2 Mediated HPV Transciptional Regulation
A-Young Lee
2009
Corpus ID: 92402311
2007
2007
Brd 4-Independent Transcriptional Repression Function of the Papillomavirus E 2 Proteins
M. Schweiger
,
Matthias Ottinger
,
Jianxin You
,
P. Howley
2007
Corpus ID: 21418039
The papillomavirus E2 protein is a critical viral regulatory protein with transcription, DNA replication, and genome maintenance…
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