BRD4 protein, human

Known as: Protein HUNK1, Bromodomain-Containing Protein 4, bromodomain containing 4 protein, human 
Bromodomain-containing protein 4 (1362 aa, ~152 kDa) is encoded by the human BRD4 gene. This protein plays a role in the mitotic process.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2018
05010020012018

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Highly Cited
2014
Highly Cited
2014
Men who develop metastatic castration-resistant prostate cancer (CRPC) invariably succumb to the disease. Progression to CRPC… (More)
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Highly Cited
2014
Highly Cited
2014
Twist is a key transcription activator of epithelial-mesenchymal transition (EMT). It remains unclear how Twist induces gene… (More)
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Highly Cited
2013
Highly Cited
2013
Chromatin regulators have become attractive targets for cancer therapy, but it is unclear why inhibition of these ubiquitous… (More)
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Highly Cited
2012
Highly Cited
2012
Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine acetylation motifs, a key event in the… (More)
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Highly Cited
2012
Highly Cited
2012
Bromodomain and extra terminal domain (BET) proteins function as epigenetic signaling factors that associate with acetylated… (More)
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Highly Cited
2012
Highly Cited
2012
Transcriptional elongation by RNA polymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in… (More)
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Highly Cited
2010
Highly Cited
2010
Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin… (More)
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Highly Cited
2009
Highly Cited
2009
The phosphorylation of the serine 10 at histone H3 has been shown to be important for transcriptional activation. Here, we report… (More)
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Highly Cited
2007
Highly Cited
2007
We have identified a conserved region in the C-terminal domain of bromodomain-containing protein 4 (BRD4) that mediates its… (More)
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Highly Cited
2003
Highly Cited
2003
The poorly differentiated carcinoma with t(15;19)(q13, p13.1) is characterized by its highly aggressive, invariably lethal… (More)
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