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Bicuculline

Known as: 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one, Bicuculline [Chemical/Ingredient], Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))- 
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
National Institutes of Health

Related topics

Related topics

17 relations

Broader (6)

AlkaloidsAnalepticsConvulsantsGABA Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (4)

bicuculline methiodidebicuculline methobromidebicuculline methochloridebicuculline methoxide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1989
Highly Cited
1989
The effects of intrathecal galanin and C-fiber stimulation on the flexor reflex in the rat
Highly Cited
1988
Highly Cited
1988
Putative neurotransmitters involved in medullary cardiovascular regulation.
Highly Cited
1986
Highly Cited
1986
Postsynaptic-gabaergic inhibition of non-pyramidal neurons in the guinea-pig hippocampus
Highly Cited
1985
Highly Cited
1985
Effects of status epilepticus on extracellular amino acids in the hippocampus
Highly Cited
1984
Highly Cited
1984
The effects of GABA and benzodiazepine receptor antagonists on the anti-conflict actions of diazepam or ethanol
Highly Cited
1982
Highly Cited
1982
Involvement of amino acids in periodic inhibitions of bulbar respiratory neurones
Highly Cited
1981
Highly Cited
1981
Disinhibitory action of acetylcholine in the rat's hippocampus: Extracellular observations
Highly Cited
1980
Highly Cited
1980
A re-evaluation of the mechanisms underlying simple cell orientation selectivity
Highly Cited
1980
Highly Cited
1980
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats
Highly Cited
1978
Highly Cited
1978
Benzodiazepine receptors: labeling in intact animals with [3H] flunitrazepam.
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