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Bicuculline

Known as: 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one, Bicuculline [Chemical/Ingredient], Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))- 
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
In a significant fraction of breast cancer patients, distant metastases emerge after years or even decades of latency. How… Expand
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Highly Cited
2002
Highly Cited
2002
We present the first global parameterization and validation of a novel charge model, called AM1‐BCC, which quickly and… Expand
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Highly Cited
2001
Highly Cited
2001
We evaluate the ability of the embedded-atom method ~EAM! potentials and the tight-binding ~TB! method to predict reliably… Expand
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Highly Cited
2001
Highly Cited
2001
A constitutive approach is developed that predicts the critical stress for twinning as a function of external (temperature… Expand
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Highly Cited
1997
Highly Cited
1997
Sporadic basal cell carcinoma (BCC) is the most common type of malignant cancer in fair-skinned adults. Familial BCCs and a… Expand
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Highly Cited
1992
Highly Cited
1992
Abstract Dislocation nucleation from a stressed crack tip is analyzed based on the Peierls concept. A periodic relation between… Expand
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Highly Cited
1992
Highly Cited
1992
Increased activity of dopamine-containing neurons in the ventral tegmental area is necessary for the reinforcing effects of… Expand
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Highly Cited
1989
Highly Cited
1989
1. Intracellular recordings were made from rat CA3 hippocampal neurones in vitro during the first eighteen days of postnatal life… Expand
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Highly Cited
1985
Highly Cited
1985
Our previous observations led to the hypothesis that cells in the substantia nigra pars reticulata (SNr) tonically inhibit… Expand
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Highly Cited
1981
Highly Cited
1981
The presence of a novel receptor for the neurotransmitter γ-aminobutyric acid (GABA) on peripheral autononric nerve terminals and… Expand
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