Bicuculline

Known as: 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)furo(3,4-e)1,3-benzodioxol-8(6H)one, Bicuculline [Chemical/Ingredient], Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))- 
An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
In a significant fraction of breast cancer patients, distant metastases emerge after years or even decades of latency. How… (More)
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Highly Cited
2005
Highly Cited
2005
During development, activation of Cl−-permeable GABAA receptors (GABAA-R) excites neurons as a result of elevated intracellular… (More)
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Highly Cited
2002
Highly Cited
2002
We present the first global parameterization and validation of a novel charge model, called AM1-BCC, which quickly and… (More)
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Highly Cited
1999
Highly Cited
1999
Small-conductance calcium-activated potassium channels (SK channels) are gated solely by intracellular calcium ions and their… (More)
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Highly Cited
1998
Highly Cited
1998
The thalamic reticular nucleus (RTN) is the major source of inhibitory contacts in the thalamus and thus plays an important role… (More)
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Highly Cited
1997
Highly Cited
1997
Anesthetic drugs are known to interact with GABAA receptors, both to potentiate the effects of low concentrations of GABA and to… (More)
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Highly Cited
1992
Highly Cited
1992
Increased activity of dopamine-containing neurons in the ventral tegmental area is necessary for the reinforcing effects of… (More)
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Highly Cited
1985
Highly Cited
1985
Our previous observations led to the hypothesis that cells in the substantia nigra pars reticulata (SNr) tonically inhibit… (More)
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Highly Cited
1981
Highly Cited
1981
The presence of a novel receptor for the neurotransmitter γ-aminobutyric acid (GABA) on peripheral autononric nerve terminals and… (More)
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Highly Cited
1970
Highly Cited
1970
The central nervous action of the alkaloid bicuculline provides pharmacological evidence that GABA is likely to be a transmitter… (More)
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